Skip to main content

Spectrum: Autism Research News

Tag: rare variants

February 2012

SHANK2 study bolsters ‘multi-hit’ gene model of autism

by  /  13 February 2012

By screening the genomes of hundreds of people with autism and analyzing the effects of newly identified mutations in cultured neurons, researchers have clarified the disorder’s link to the SHANK2 gene.

3 Comments

Genetics: X chromosome disorder linked to autism

by  /  7 February 2012

Duplication of a region on the X chromosome leads to a genetic disorder characterized by severe autism, according to a study published 25 November in Annals of Neurology.

0 Comments
January 2012

Risky business

by  /  24 January 2012

The genome-wide association study has been the favorite whipping post among some geneticists, but three new reviews come to its defense.

1 Comment

New resource compiles data on autism-linked genes

by  /  18 January 2012

A new online database provides searchable information for nearly 10,000 genes, variants and chromosomal regions linked to autism. Researchers describe the resource, dubbed AutismKB, in the January issue of Nucleic Acids Research.

0 Comments

Genetics: X chromosome gene linked to autism in males

by  /  18 January 2012

TBL1X, a gene located on the X chromosome, is associated with autism in males but not in females, according to a study published 3 November in Molecular Autism.

0 Comments

Molecular mechanisms: DISC1 variants inhibit neurogenesis

by  /  13 January 2012

Three variants of DISC1, a gene implicated in schizophrenia and autism, may disrupt the formation of new neurons in the brain, according to a study published 17 November in Neuron.

0 Comments

Genetics: Large variants linked to intellectual disability

by  /  10 January 2012

Intellectual disability is more likely to be associated with multiple, large or non-inherited duplications and deletions of DNA than is autism, according to a study published 7 November in PLoS Genetics.

0 Comments

Funding fears prevent researchers from sharing their mice

by  /  9 January 2012

Despite funders’ requirements to share mouse models after publication, many researchers hoard the animals for the good of their labs — and that could have an adverse effect on the field as a whole.

0 Comments
December 2011

Genetics: Family pedigrees suggest autism gene candidates

by  /  14 December 2011

Researchers have identified 12 duplications or deletions of DNA regions that are transmitted along with autism in families with a history of the disorder. The results were published 7 October in PLoS One.

0 Comments

Eric Kandel: The way forward for autism research

by ,  /  6 December 2011

Studying the cellular and molecular mechanisms that underlie autism is crucial to advancing our understanding of the disorder, says neuroscientist Eric Kandel.

1 Comment