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Tag: organoids

September 2021
neurons in organoids
News

Protein inhibitor normalizes neuronal migration in organoid model of autism

by  /  1 September 2021

Inhibiting a protein that helps cells move or change shape prevents atypical neuronal migration in 3D clusters of brain cells carrying autism-linked genetic variants.

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August 2021
Holly Stessman standing in her garden looking up and holding her two chickens.
Opinion / Q&A

Beyond the Bench: A conversation with Holly Stessman

by  /  13 August 2021

When Holly Stessman isn’t probing autism genes, she is tending to her flock of chickens or seeking out the next great sci-fi movie.

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June 2021
News

Enzyme blockers may counteract excess protein levels in fragile X syndrome

by  /  7 June 2021

Investigational drugs that inhibit an overactive enzyme could partially normalize how brain cells mature in boys with fragile X syndrome.

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April 2021
By imaging spheroids in 3D, researchers can see structures called rosettes, in which immature brain cells (green) surround a cavity (pink), of a variety of shapes and sizes.
News / Toolbox

Airy beams capture 3D structures inside spheroids

by  /  8 April 2021

An imaging approach that captures spheres of brain cells in three dimensions could illuminate processes in early brain development.

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March 2021
Tiny cortical organoids in petri dish
News

Year-old organoids echo genetic shifts seen at birth

by  /  8 March 2021

3D cultures of human brain cells kept alive for more than a year undergo transitions in gene activity that resemble those seen in newborns, and may be used to study autism genes in postnatal stages of brain development.

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February 2021
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.
News

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

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January 2021
organoids in early stages of development.
News

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

by  /  11 January 2021

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

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December 2020
Brain organoid with multiple stains; red and green, to indicate cells.
News / Toolbox

New method probes genes’ function in brain organoids

by  /  16 December 2020

A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.

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June 2020
News

Study links gene to inherited form of autism

by  /  25 June 2020

Mutations in both copies of a gene called ACTL6B lead to autism, epilepsy and intellectual disability.

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February 2020
Brain organoid cells look different than those in embryonic brain tissue-grid of six images show growth of both types over time.
News / Toolbox

Cell stress may sap organoids’ usefulness in autism research

by  /  26 February 2020

Some cells in brain organoids — 3D clusters of cultured brain cells — fail to develop fully.

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