The method, called Orgo-Seq, reveals that a deletion of genes on chromosome 16 increases the proportion of immature neurons and neural precursors in brain organoids derived from people with the mutation.
Spectrum: Autism Research News
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
A handful of scientists are committed to advancing research on the autism-related genetic conditions their own children have.
Strategies to replace or compensate for mutated copies of the TCF4 gene could lead to treatments for this profound form of autism, a new study suggests.
The size of the cerebral cortex seems to depend on when neural progenitor cells multiply or differentiate into glial cells and neurons.
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.
Cortical organoids that contain non-neuronal brain cells called microglia may reflect human neurodevelopment more faithfully than those that don’t.
Inhibiting a protein that helps cells move or change shape prevents atypical neuronal migration in 3D clusters of brain cells carrying autism-linked genetic variants.
When Holly Stessman isn’t probing autism genes, she is tending to her flock of chickens or seeking out the next great sci-fi movie.