Skip to main content

Spectrum: Autism Research News

Tag: organoids

July 2022

Sequencing trick identifies brain cells affected by large autism-linked mutation

by  /  25 July 2022

The method, called Orgo-Seq, reveals that a deletion of genes on chromosome 16 increases the proportion of immature neurons and neural precursors in brain organoids derived from people with the mutation.

0 Comments
Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

0 Comments

The most personalized medicine: Studying your own child’s rare condition

by  /  7 July 2022

A handful of scientists are committed to advancing research on the autism-related genetic conditions their own children have.

0 Comments
June 2022

Organoids test gene therapies for Pitt-Hopkins syndrome

by  /  2 June 2022

Strategies to replace or compensate for mutated copies of the TCF4 gene could lead to treatments for this profound form of autism, a new study suggests.

0 Comments
May 2022

Organoids hint at origins of enlarged brains in autistic people

by  /  13 May 2022

The size of the cerebral cortex seems to depend on when neural progenitor cells multiply or differentiate into glial cells and neurons.

0 Comments
April 2022
organoids in early stages of development.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

by  /  19 April 2022

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

0 Comments
February 2022

Three autism-linked genes converge on tweaks to cells’ timing

by  /  2 February 2022

Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.

0 Comments
November 2021

Including immune cells in brain organoids improves model’s accuracy

by  /  15 November 2021

Cortical organoids that contain non-neuronal brain cells called microglia may reflect human neurodevelopment more faithfully than those that don’t.

0 Comments
September 2021
neurons in organoids

Protein inhibitor normalizes neuronal migration in organoid model of autism

by  /  1 September 2021

Inhibiting a protein that helps cells move or change shape prevents atypical neuronal migration in 3D clusters of brain cells carrying autism-linked genetic variants.

0 Comments
August 2021
Holly Stessman standing in her garden looking up and holding her two chickens.

Beyond the Bench: A conversation with Holly Stessman

by  /  13 August 2021

When Holly Stessman isn’t probing autism genes, she is tending to her flock of chickens or seeking out the next great sci-fi movie.

0 Comments