Change of heart and mind: Autism’s ties to cardiac defects
Children with congenital heart disease have an increased likelihood of autism. Why?
Children with congenital heart disease have an increased likelihood of autism. Why?
Connections between 13 autism-linked proteins and their binding partners in excitatory neurons implicate a new molecular pathway.
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.
Scientists have at last filled in the missing gaps — an advance likely to inform every aspect of autism genetics research, Eichler says.
The more scientists dig into DNA, the more intricate its contribution to autism seems to be. Here, we unravel the complex genetics of autism.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Researchers expand on the already enormous progress made on the Human Proteome Project
An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.
Autism may stem from a different — and larger — set of genetic mutations in women than it does in men.