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Spectrum: Autism Research News

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The latest developments in autism research.

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Tuan Chao speaks about her research.

Tying PPFIA3 to autism: A quick take at SfN with Tuan Chao and Maimuna Paul

by  /  15 November 2022

Work in fruit flies has helped Paul decode a neurodevelopmental syndrome in children caused by rare de novo variants in the gene PPFIA3.

Still image showing activity of activity of neurons with genetic mutations in the 15q11-13 chromosomal region.

Single gene insufficient to account for dup15q, Angelman traits

by  /  18 November 2022
UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.
Two white mice socialize.

Autism genes converge on disruptions in social brain circuit

by  /  17 November 2022
The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.
An older woman with gray hair sits on a couch and speaks with a clinician.

Brain’s memory center flags autistic adults at risk for cognitive decline

by  /  17 November 2022
Brain scans of the hippocampus reveal autistic people who are at increased risk of cognitive problems as they get older.

Latest News

Geometric black-and-white brain model over a grid.

Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism

by  /  22 November 2022

The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.

Light micrograph of microglia cells stained with Rio Hortega’s silver carbonate method.

Autism’s sex bias tied to glial, immune cell gene expression

by  /  22 November 2022

The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.

Grid of nine mri scans of mouse brains.

Shared brain structure, connectivity hint at autism subgroups

by  /  21 November 2022

Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.

Image of organoids modeling CDKL5 deficiency disorder.

Organoids identify potential therapies, circuit flaws for autism-linked syndromes

by  /  21 November 2022

Brain cell clusters serve as drug screens and reveal connectivity differences for autism-linked conditions, two new models show.

Speech bubble formed by a network of communication

Community Newsletter: Highlights from Neuroscience 2022

by  /  20 November 2022

This week we’re highlighting the Twitter chatter from the Society for Neuroscience’s annual meeting, held in San Diego, California, last week.

Marco Pagani stands in front of his research poster.

Subtyping autism using fMRI: A quick take at SfN with Marco Pagani

by  /  18 November 2022

Pagani used mouse models to connect autism etiologies to brain connectivity alterations and then found similar alterations in people with idiopathic forms of the condition.

Still image from video of zebrafish swimming in small enclosures.

Zebrafish social behavior swims into mainstream

by  /  17 November 2022

New studies bolster the idea that zebrafish models can say something meaningful about social behavior in autism.

Ellen Hoffman sits in a chair and smiles.

Screening zebrafish autism models: A quick take at SfN with Ellen Hoffman

by  /  16 November 2022

Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.

A white mouse sits on a nest against a blue background.

Mouse models help sniff out olfactory differences in autism

by  /  16 November 2022

A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.

White laboratory mice isolated on orange luminous glass surface.

New evidence hints at mechanisms for ‘fever effect’ in autism

by  /  15 November 2022

The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.

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