Treatment with the insulin-like growth factor (IGF) greatly improves the health of mouse models of Rett syndrome ― a regressive genetic disorder that causes mental retardation, seizures, and autistic features ― according to unpublished researched presented this morning at the Society for Neuroscience conference.
Schizophrenia may be a consequence of neuronal birth gone awry, according to unpublished research presented today at the Society for Neuroscience conference.
Brain tissue from individuals with autism is rare, to say the least: of the 30,000 samples in the National Institutes of Healthʼs Brain and Tissue Bank for Developmental Disorders, for instance, only 30 are from individuals diagnosed with autism.
A mouse model of neurofibromatosis ― a genetic neurodevelopmental disorder that leads to nerve tumors, memory problems and, often, autism ― exhibits deficits in social interaction and social learning, according to research presented in a poster session today at the Society for Neuroscience conference.
For decades, those who study brain cell activity have faced a fundamental trade off: either closely monitor the activity of a single cell or look at the circuit level to see how large groups of neurons communicate with each other.
Deletions or duplications of a specific segment of chromosome 16 ― which has previously been fingered as a ‘hotspotʼ for autism susceptibility ― may be present in a surprising number of people who don’t have autism, according to researchers presenting preliminary data today at the annual meeting of the Child Neurology Society in Santa Clara, California.
In the fall of 1980, when he left his hometown of St. Louis, Missouri, for undergraduate studies at Cornell University in upstate New York, John Constantino was determined to pursue one of two careers: a doctor or a school teacher.
Mutations in the two genes that cause the disease tuberous sclerosis complex, or TSC, interfere with the normal formation of axons, the long and thin strands that conduct electrical signals between brain cells, researchers contend in a report in Genes and Development.
A specific gene in the chromosomal region 22q11 is important for normal brain connectivity and synapse formation, and its absence may lead to schizophrenia, researchers are reporting today in Nature Neuroscience. The same team first linked a deletion in the chromosomal region to the disorder 13 years ago.
In the past year, researchers have debuted a growing number of mouse models that they say exhibit the subtle behaviors of autism. In the midst of controversy over whether these mouse models represent autism, one team of scientists is looking for quirks in the animalsʼ neural circuits.