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Spectrum: Autism Research News

Tag: Simons Simplex Collection

July 2023
Blurry photograph of a crowd of people on a street.

Some who lack autism diagnosis carry variants tied to the condition

by  /  13 July 2023

The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.

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June 2023
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Modified MRI; father findings

by  /  22 June 2023

This month’s newsletter tackles null findings from an attempted replication of a “revolutionary” MRI approach and an analysis of family genetics.

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October 2022
Illustration of an X chromosome against a black background.

X-chromosome variants help explain autism’s sex bias

by  /  24 October 2022

The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.

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August 2022
Conceptual illustration of a DNA double helix

Scans of sundry variant types uncover autism-linked genes

by  /  18 August 2022

Troves of sequencing data reveal genes tied to autism through different variant types, providing a more complete picture of the condition’s genetic roots and new clues to its heterogeneity.

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Mutations disrupting chromatin interactions contribute to autism

by  /  8 August 2022

The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.

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July 2022
Figure in space heads towards unknown, dark area.

The final frontier: Autism geneticists take on the noncoding genome

by  /  12 July 2022

The vast stretches of DNA that don’t code for proteins could fill key knowledge gaps about autism genetics. But making sense of it all won’t be easy.

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June 2022
Illustration of two figures in a field of black circles representing genetic risks. The circles surround the figure on the left and stay farther away from the figure on the right.

Common inherited variants tied to autism show sex bias in families

by  /  23 June 2022

Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.

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A street crowded with pedestrian traffic

Spectrum of variants contribute differently to autism traits

by  /  3 June 2022

Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.

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May 2022
Three views of zebrafish.

Novel gene linked to brain size in autistic people

by  /  16 May 2022

The gene, YTHDF2, may be one of several that contribute to an autism subtype marked by an unusually big brain.

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October 2021
Simple flat color DNA helix in two tones of blue.

Autism-linked genetic variants increase, decrease intelligence

by  /  19 October 2021

Common and rare variants in or near autism-associated genes can have opposite effects on cognition.

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