Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
But the alternatives, including living-brain biopsies, raise logistical and ethical questions, experts say.
Genes exert their strongest influence on the brain in the first half of gestation — a key window for autism and other neurodevelopmental conditions.
Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.
Such high expression levels may account for the condition’s sex bias, a new preprint suggests — but not everyone agrees with that logic.
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
People with dup15q syndrome and those with idiopathic autism have similar patterns of altered gene expression in early brain development and later in life.
The prize recognizes Geschwind’s contributions to our understanding of autism genetics.
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.