We checked in from the 2013 International Meeting for Autism Research with daily reactions from this year’s attendees.

A candidate drug for Angelman syndrome shows promise in activating the gene silenced in people with the disorder, and only that gene. Why doesn’t it unsilence other genes?

Online tools to collect data on children with autism provide an opportunity to expand sample sizes and reach a broader audience. But how far can these tools go in replacing traditional clinical evaluations?

Exome sequencing has produced a wealth of insight into the heritability of autism and identified a number of promising risk genes. But how much risk lies outside the exome?

In his Directors’ Column, Alan Packer points out how a number of autism risk genes act on a common cellular pathway regulated by a single protein. What other similar convergent paths might be hiding in the literature? Let’s go on a treasure hunt.

Growing evidence suggests that abnormal connectivity in the brain underlies autism, but conflicting interpretations persist about where and how the dysfunction occurs. How do we investigate the underlying mechanisms of this theory?

Watch the complete replay of Jonathan Kipnis discussing his groundbreaking work connecting microglia and peripheral immunity to autism. Submit your own follow-up questions.

An imbalance in the excitatory and inhibitory signaling between neurons seems to play a critical role in autism. What can we do with that information?

In December, SFARI brought together a group of scientists studying the connection between microglia and autism. These scientists are trying to delineate the next steps for this emerging field. Join the conversation.

Watch the complete replay of Vikaas Sohal’s webinar on abnormal neural circuits in autism. Submit your own follow-up questions.