Spectrum: Autism Research News

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

People with autism who carry DNA variants in the same protein-coding region of a gene have more similar cognitive abilities and behaviors than those who carry mutations in different regions of the same gene.

All five participants in a clinical trial of a gene therapy for Angelman syndrome experienced leg weakness, leading sponsors to pause the study.

An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.

Neurons derived from people with 22q11.2 deletion syndrome show deficits in calcium signaling and electrical activity, pointing to possible therapeutic targets.

Biomedical research costs money. And applying for research funding can be a long and complicated process.

A new study highlights the challenge of distinguishing genetic variants linked to autism from those associated with cognitive development.

Many genes in a brain region implicated in autism change expression patterns in late fetal development, depending on differences in neighboring DNA.