Some children with autism carry harmful mutations in the DNA found in mitochondria, the cell’s energy producers.
Spectrum: Autism Research News
Tag: simplex families
Large autism-linked mutations tend to be inherited in families with a history of the condition. By contrast, they often arise spontaneously in families with a single affected person.
A study of more than 2,500 families that have at least one child with autism has found three factors that predict autism symptoms in an unaffected sibling.
An online portal designed to give researchers easy access to genomic data may unwittingly reveal some sensitive information.
Many children with autism have gastrointestinal problems, seizures and sleep disorders. A new study suggests that these seemingly disparate conditions are interconnected and may lead to the children’s behavioral issues.
Less than one-third of sibling pairs with autism who carry rare mutations in autism-linked genes share those mutations, according to the largest study yet to sequence whole genomes of people with the disorder. The study questions the assumption that autism’s risk factors run in families, but some experts are skeptical.
Boys with autism who carry rare, spontaneous mutations have lower intelligence quotients and more severe symptoms than do those who may have inherited the disorder. The finding, published 21 October in the Proceedings of the National Academy of Sciences, hints at two classes of autism risk with varying severity.
Analyzing the sequences of more than 20,000 people, researchers have unearthed the largest and most robust list of autism genes so far, they reported today in Nature.
Having an enlarged head in early childhood is not a reliable marker of autism, according to two new studies that tracked changes in head and body size in children over time.