Researchers have launched an effort to yoke together disparate gene sequencing projects in the U.S., Canada and the U.K., aiming to double the number of known autism-related genes in the next three to four years.
Spectrum: Autism Research News
Tag: simplex families
A genetic defect in the synthesis of carnitine, a molecule that is essential for proper mitochondrial function, might slightly increase risk for autism in some children, according to research published 8 May in the Proceedings of the National Academy of Sciences.
The largest set of exome sequencing studies of children with autism and their families to date has identified a handful of genes that may increase risk of the disorder, according to research published in Nature.
In families that have at least one child with autism, significant motor impairments crop up in most children with the disorder and hardly any of their unaffected siblings, according to a study published 19 October in Autism.
Individuals who have autism show distinct patterns of gene expression in neurological pathways compared with their unaffected siblings, according to unpublished work presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.
Two studies published in the past month highlight the challenges in balancing the accuracy of autism diagnosis with cost-effectiveness and speed.
Individuals who have multiple children with autism have more severe social and communication deficits than either controls or those who have only one child with autism.
Researchers have identified autism-linked mutations using a technique that can detect deletions or duplications of DNA spanning a single gene.
The largest and most ambitious genome-sequencing project to date aims to identify rare variants and study their association to disease traits in 10,000 people.