Tweaks to autism-linked pathway tilt circuits’ signaling balance
Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.
Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.
Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.
Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.
Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
The expression levels of certain genes that track with brain activity are different in autistic people than in their non-autistic peers.
Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.
The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.