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Tag: CRISPR

December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
Features / Special Reports / Hindsight is 2020: The year in review

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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White lab mouse sitting in a gloved hand.
Features / Special Reports / Hindsight is 2020: The year in review

Notable papers in autism research, 2020

23 December 2020

Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.

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Mutated cells in mouse embryos--the mutations are seen in pink
News

Autism genes affect development of neurons and glia

by  /  11 December 2020

Researchers have devised a new way of seeing how gene mutations affect cells during development.

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November 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
News

Prenatal CRISPR therapy blocks Angelman syndrome traits in mice

by  /  9 November 2020

A gene-editing treatment shows long-lasting effects in a mouse model of Angelman syndrome, a genetic condition related to autism.

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October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.
Features / Deep Dive

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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September 2020
Zebrafish embryos with various deformities.
News / Toolbox

CRISPR technique knocks down gene expression in animal embryos

by  /  2 September 2020

A new method that suppresses gene expression in the embryos of fish and mice may help researchers study autism genes in early development.

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November 2019
Micrograph of mouse brain showing transplanted human microglia
News / Toolbox

Chimeric mouse model aids study of brain’s immune cells

by  /  15 November 2019

A new technique allows researchers to transplant human microglia into mouse brains and better study the association between these cells and autism.

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Chromosomes swapping DNA
News / Toolbox

CRISPR technique tracks genetic activity in real time

by  /  8 November 2019

A new method scans gene expression in live cells and could help scientists study autism genes.

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October 2019
News

Gene-edited marmosets may mimic Rett syndrome traits

by  /  23 October 2019

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

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Two pairs of neurons shown in red.
News

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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