Tag: rapamycin

August 2018
Two scientists standing in a lab.
News / Profiles

Family ties: Sabatini brothers crack codes that may underlie autism

by  /  30 August 2018

David and Bernardo Sabatini, brothers born just a year and a half year apart, invent their way to answering big questions about autism.

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January 2018
group of rats on wood chips
News

Drug in trials for one autism-linked condition may worsen another

by  /  26 January 2018

The drug rapamycin, which is in clinical trials as a treatment for tuberous sclerosis, may exacerbate features of fragile X syndrome, another condition related to autism.

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November 2017
Mice missing the tuberous sclerosis gene in astrocytes have frequent seizures.
News

Cancer drug wards off seizures in mouse model of tuberous sclerosis

by  /  13 November 2017

A drug called rapamycin prevents seizures in a mouse model of the autism-related condition tuberous sclerosis complex.

2 Comments
January 2017
Features / Deep Dive

The curious connection between autism and cancer

by  /  11 January 2017

A surprising number of genes associated with autism also have links to cancer. Does that mean cancer drugs can treat autism?

0 Comments
May 2016
Features / Deep Dive

The gene hunters

by  /  18 May 2016

Criss-crossing the globe on a quest for unusual DNA, researchers have discovered a rare mutation that promises insights into both epilepsy and autism — and points to a treatment.

1 Comment
November 2014
News

Treatment prevents autism-like symptoms in ‘teenage’ mice

by  /  16 November 2014

A treatment that targets the genetic defect in tuberous sclerosis prevents autism-like symptoms in mice at 6 weeks of age — the mouse equivalent of adolescence. Researchers presented the unpublished results yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
 

1 Comment
September 2014
News

Brains of children with autism teem with surplus synapses

by  /  4 September 2014

The brains of children with autism do not prune unneeded connections between neurons as they age, leaving them with too many of these neuronal links, according to a study published 21 August in Neuron.

6 Comments
January 2014
News

Mounting evidence implicates cerebellum in autism

by  /  6 January 2014

Results from four studies published in the past year point to a role for the cerebellum in autism-related behaviors.

8 Comments
June 2013
News

Signaling imbalance may underlie tuberous sclerosis complex

by  /  17 June 2013

The mutation that causes tuberous sclerosis complex, an autism-related disorder, may disable calming signals in the brain, leading to hyperactive neurons, according to a study published 8 May in Neuron.

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July 2012
News

Tuberous sclerosis gene loss triggers autism-like features

by  /  26 July 2012

Losing one or both copies of TSC1, one of the two genes responsible for tuberous sclerosis complex, in specific cells of the cerebellum can trigger several autism-like behaviors in mice, according to research published 1 July in Nature.

1 Comment