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Spectrum: Autism Research News

Tag: rapamycin

March 2022
Micrograph of neuron dendrite segments.

Maternal sleep apnea may contribute to autism-like traits in rats

by  /  18 March 2022

Pups born to mothers that experience low oxygen during sleep have overactive mTOR signaling, which has been linked to some forms of autism.

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Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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November 2021

Synaptic overgrowth, hyperconnectivity may define autism subtype

by  /  18 November 2021

Model mice of the subtype also show hyperactivity in a signaling pathway called mTOR, bolstering the idea that distinct forms of autism have different biological roots and may require different treatment approaches.

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August 2021

Molecular overlap links tuberous sclerosis, fragile X

by  /  16 August 2021

Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.

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March 2020
Illustration showing the human brain with neurons made out of flower shapes and the cerebellum highlighted in gold and yellow.

Brain’s motor hub plays unsung role in social skills, cognition

by  /  9 March 2020

Long known as the director of movement, the cerebellum may also coordinate social and cognitive abilities, including those central to autism.

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November 2019

Mouse study reveals overlooked target for autism therapies

by  /  20 November 2019

Blocking one form of an enzyme implicated in autism eases unusual behaviors and seizures in mice missing a top autism gene.

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September 2019
row of babies playing with toys that look like genome sequence

Studies of tuberous sclerosis may shed light on biology of autism

by  /  24 September 2019

Tuberous sclerosis provides a unique opportunity to understand autism because about half of people with that single-gene condition also have autism.

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August 2018
Two scientists standing in a lab.

Family ties: Sabatini brothers crack codes that may underlie autism

by  /  30 August 2018

David and Bernardo Sabatini, brothers born just a year and a half year apart, invent their way to answering big questions about autism.

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January 2018
group of rats on wood chips

Drug in trials for one autism-linked condition may worsen another

by  /  26 January 2018

The drug rapamycin, which is in clinical trials as a treatment for tuberous sclerosis, may exacerbate features of fragile X syndrome, another condition related to autism.

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November 2017
Mice missing the tuberous sclerosis gene in astrocytes have frequent seizures.

Cancer drug wards off seizures in mouse model of tuberous sclerosis

by  /  13 November 2017

A drug called rapamycin prevents seizures in a mouse model of the autism-related condition tuberous sclerosis complex.

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