Autism and epileptic seizures often go hand in hand. What explains the overlap, and what does it reveal about autism’s origins?
Deleting an autism gene called TRIO derails neurons’ journey to their destination.
An experimental drug that muffles the activity of neurons in the skin moderates heightened reactions to touch in six mouse models of autism.
Mutations in the autism gene NLGN3 may alter the gut nervous system of mice.
Mice colonized with gut microbes from some autistic boys show behaviors like those of the boys.
The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.
The brains of rats exposed in utero to the seizure drug valproate show a significant increase in brain size around the time of birth.
Administering a cholesterol drug alongside an antibiotic eases atypical behavior and restores the signaling balance in the brains of people with fragile X syndrome.
Specialized neurons called chandelier cells, which dampen brain signals, make unusually few connections in the brains of people with autism.