A semirural Colombian town called Ricaurte is home to the largest recorded genetic cluster of people with mutations linked to fragile X syndrome.

Researchers have used transcranial magnetic stimulation to show that people with fragile X syndrome have weak ‘inhibitory’ signals, those that dampen neuronal activity in the brain.

Sleep problems in autism may stem from the same biological changes that underlie the core features of the condition.

Deleting FMR1, the gene mutated in fragile X syndrome, in subsets of mouse neurons leads to distinct features of the condition.

Researchers should proceed with caution when studying the behavior of one of the most popular mouse models of autism: the fragile X mouse model.

Problems with social interactions stem from faulty wiring of a single circuit spanning distant brain regions, results from three mouse models of autism suggest.

Differences in brain structure may distinguish boys with relatively mild features of fragile X syndrome from those with a severe form of the condition.

In people with fragile X syndrome, autism is often accompanied by seizures, trouble falling or staying asleep and anxiety.

A cannabis gel may ease features of fragile X syndrome, omega fatty acids show promise for autism in two trials, and oxytocin reinforces social behaviors through the brain’s reward pathway.

Mice missing FMR1, the gene mutated in fragile X syndrome, have an atypical brain response to meeting an unfamiliar mouse.