Skip to main content

Spectrum: Autism Research News

The not-so-simple synapse

by  /  13 June 2008
THIS ARTICLE IS MORE THAN FIVE YEARS OLD

This article is more than five years old. Autism research — and science in general — is constantly evolving, so older articles may contain information or theories that have been reevaluated since their original publication date.

Try this on for size: the human brain has about 100 billion neurons, connected by 100 trillion synapses.

We already knew that the human brain has many more neurons than the brain of any other animal, and is three times as large as even its closest relative, the chimpanzee.

In a paper in Nature Neuroscience on Sunday, scientists reported another clue to the human brainʼs superiority: synapses become increasingly more complex as you climb the evolutionary scale from single-celled yeast to humans.

In the human brain, these 100 trillion protein-rich synapses help form specialized regions that are responsible for language, social communication, learning and memory ― all of which are affected in diseases such as autism.

There is ample evidence that synapses may be intricately involved in autism.

Mutations in neuroligins and neurexins, which together help assemble and tether synapses, are associated with the disorder; and mutations in SHANK3, a scaffolding protein, are thought to account for up to one percent of autism cases.


TAGS:   autism