Martin Picard of Columbia University detailed his team’s study, “Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice,” published in Nature Communications 10 August. Spectrum published a collection of coverage on the link between mitochondria and autism earlier this week.
How we interact with the world – our perceptions, reactions, behaviors – are driven by brain biology. But what part?
We find that mitochondrial energy production capacity in specific brain areas explains a large fraction of mouse behavioral differences https://t.co/UzrfjNJ1Oa
— Martin Picard (@MitoPsychoBio) August 11, 2023
Such a fantastic comprehensive paper from @MitoPsychoBio lab characterizing stress effects on mitochondria across the brain. So happy to have been part of this great collaboration! https://t.co/1ciJs9LlYa
— Christoph Anacker (@Der_Scientist) August 14, 2023
Wow! Up to 50% of between animal behaviors are attributable to differences in cortico-striatial mitochondrial function! Not that surprising considering that mito control neuronal firing, neurogenesis, plasticity, and lots of glial functions, but so freaking cool to map this out! https://t.co/UKqcN2bF8u
— D. Parker Kelley (@sequencemyneuro) August 13, 2023
Maiko Uemura of Kyoto University and Stefano Berto of the Medical University of South Carolina commented on the study, “Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis,” published in Nature Neuroscience 10 August.
The organoids derived form iPSCs of boys with idiopathic autism spectrum disorder (ASD) and their unaffected fathers revealed that ASD pathogenesis involved a disruption of the balance b/w excitatory neurons of the dorsal cortical plate and other lineages.https://t.co/pQ4mwpL3vC
— Maiko Uemura, MD, PhD (@UemuraMaiko) August 15, 2023
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Amazing paper from Vaccarino lab! https://t.co/G1Yztizp68
— Stefano Berto, PhD (@StefanoBerto83) August 14, 2023
— Ashlea Segal (@AshleaSegal) August 14, 2023
Tim Lawn of Kings College London replied to Segal.
Really great work! One of those obvious elegant ideas you can’t believe didn’t occur to you. Also… “Normative modeling of other phenotypes, such as those obtained with functional or molecular imaging, may reveal stronger separation between groups” –> watch this space???? https://t.co/X09kmnjQ3u
— Tim Lawn (@lawn_tim) August 15, 2023
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Steven Sheridan of Harvard University linked to his team’s study, “Loss of function in the neurodevelopmental disease and schizophrenia-associated gene CYFIP1 in human microglia-like cells supports a functional role in synaptic engulfment,” published in Biological Psychiatry 10 August.
Alfred George, Jr. of Northwestern University shared his team’s study, “Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties,” published in the Journal of General Physiology 14 August.
Very proud to see our latest work on #SCN2A online @JGenPhysiol. Great work by Chris Thompson (@Channelsrus25) in collaboration with @JohnMillichapMD. Might be the first time patch clamp data are presented as volcano plots. https://t.co/R2D73VAcCh
— Al George (@nupharm1) August 14, 2023
— Takei Lab (@LabTakei) August 13, 2023
That’s it for this week’s Community Newsletter! If you have any suggestions for interesting social posts you saw in the autism research sphere, feel free to send an email to [email protected].
Cite this article: https://doi.org/10.53053/AUEH6784