Adam Glaser of the Allen Institute detailed his team’s preprint, “Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues,” posted on bioRxiv 11 June.
How do you image the large and the small at the same time? We developed new ???? technology to image centimeter-scale specimens – including whole mouse brains ??? – with diffraction-limited resolution and without sectioning. #mesoscale #imaginghttps://t.co/Kl7ZURNpdM
???? (1/n) pic.twitter.com/m1bvSORsuI
— Adam Glaser (@adam_k_glaser) June 12, 2023
Jayson Jeganathan of the University of Newcastle in Australia posed a question, which Glaser answered.
Definitely. The combination of the resolution, field of view, imageable tissue thickness, and blazing speed (nearly 10^9 voxels/sec) makes this an ideal method for larger brains.
— Adam Glaser (@adam_k_glaser) June 14, 2023
Bryan Jones of the University of Utah responded to Glaser.
This is a massive advancement for projectomics. Some neurons in neural systems are truly long range projections, and tracking those has been problematic. I cannot wait to see these tools applied to neurodegenerative diseases. https://t.co/LaNxmtqshv
— Bryan William Jones (@BWJones) June 12, 2023
Mackenzie Mathis of École Polytechnique Fédérale de Lausanne, Jacqui Marshall of Cancer Research UK and Wim Crusio of Université de Bordeaux posted the article “Lab mice go wild: Making experiments more natural in order to decode the brain,” published in Nature 14 June.
Studying both natural & skilled behavior is critical to understand the brain. I’m very happy tools we develop- @deeplabcut– are used so broadly ????& openning new research in neuro and ecology
New @Nature news piece re: lab????: https://t.co/eubr87t0M9
Wild:https://t.co/zF82MyRP3P pic.twitter.com/45UCcVOQYo
— Mackenzie Mathis, PhD (@TrackingActions) June 15, 2023
Do we, as scientists, think enough about how our experiments would correspond to the real world?
????Useful to consider how well our results might be generalised into real world scenarios! https://t.co/8JykbA8ylm
— Dr Jacqui Marshall CSci ILM5-Dip ???????????????????????????????? (@JacquiMarshall2) June 15, 2023
Robert Gerlai and @nickyclayton22 already argued for this in 1999 and Hanspeter Lipp has been running experiments in naturalistic settings since the mid 1990s.
2/https://t.co/ZhCeJe0Ynw— Wim Crusio (@WimCrusio) June 15, 2023
Nikola Grujic of Eidgenössische Technische Hochschule Zürich explained his team’s study, “Control and coding of pupil size by hypothalamic orexin neurons,” published in Nature Neuroscience 19 June.
Pupil size is used in many many studies as a readout of behavioural arousal. In our new work in @NatureNeuro we add to the literature on neural control of pupil size by demonstrating a strong impact of orexin neurons. (1/3)https://t.co/SAR1sBGA7H
— Nikola Grujic (@umochitju) June 19, 2023
Seán Froudist-Walsh of the University of Bristol describes his team’s paper, “Gradients of neurotransmitter receptor expression in the macaque cortex,” published in Nature Neuroscience 19 June.
Gradients of neurotransmitter receptor expression in the macaque cortex, out now in @NatureNeuro. https://t.co/xjUGWFbCNG Our findings: 1/7
— Seán Froudist-Walsh (@seanfw) June 19, 2023
Nathan Spreng of McGill University and Chris Klink of Universiteit Utrecht responded to Froudist-Walsh.
🙂 There are! We haven’t quantified them yet. More work is on the way on this from Nicola Palomero-Gallagher’s group, including a voxel-wise reconstruction of the whole brain led by postdoc Thomas Funck
— Seán Froudist-Walsh (@seanfw) June 20, 2023
Thanks Chris. RheMAP is great, but that was exactly the issue that stopped us from providing the maps in other templates already. It seems a solvable issue, but one that would require a bit of work
— Seán Froudist-Walsh (@seanfw) June 21, 2023
Rosa Hoekstra of King’s College London linked to her team’s study, “Non-specialist delivery of the WHO Caregiver Skills Training Programme for children with developmental disabilities: Stakeholder perspectives about acceptability and feasibility in rural Ethiopia,” published in Autism 16 May.
Paper alert! We previously adapted the @WHO caregiver skills training for use in Ethiopia and pre-tested in a specialist setting. But is it feasible to train non-specialists to deliver the programme in rural context? Paper freely available here: https://t.co/EQxpTReYvj pic.twitter.com/eSJ3r3lTQ2
— Dr Rosa Hoekstra (@rosa_hoekstra) June 8, 2023
Kathy Leadbitter of the University of Manchester commented on the study, and Hoekstra replied.
Yes, I think parent- child play through toys is ultimately quite a western concept. Ethiopian parents can certainly be playful with their children. But the idea to sit on the floor to play with your child with toys is uncommon, and I think that’s true in many countries.
— Dr Rosa Hoekstra (@rosa_hoekstra) June 8, 2023
Autism in Adulthood announced the release of its special issue.
We are so pleased to announce that our Special Issue dedicated to the intersection of autism and the broad LGBTQ+ is online now.
ALL papers FREE to 15 Jul:https://t.co/q1ATDPt0VH pic.twitter.com/GCfsWkjXOm
— AutismInAdulthood (@AutismAdulthood) June 16, 2023
Shreejoy Tripathy of the University of Toronto shared his team’s preprint, “BrainRBPedia: A resource for RNA-binding proteins relevant to neurodevelopmental disorders,” posted on bioRxiv 9 June.
I’m proud of this @biorxivpreprint on BrainRBPedia, a resource for RNA-binding proteins relevant to neurodevelopmental disorders, led by Kara Han while she was a @UofT BCB ugrad in my lab! https://t.co/xZwnNCGkhl pic.twitter.com/h9JGcIi7NV
— Shreejoy Tripathy (@neuronJoy) June 20, 2023
Science posted a link to the article “PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production,” published in Science Translational Medicine 31 May.
New in @ScienceTM: Researchers have identified 15 separate variants in the PSMC3 proteasome gene in 23 patients with neurodevelopmental delay and intellectual disabilities. https://t.co/auKeeA9ZG5 pic.twitter.com/KGR6lqnQSs
— Science Magazine (@ScienceMagazine) June 14, 2023
Marc Seal of the University of Melbourne shared a link to the preprint “Mapping neurodevelopmental diversity in executive function,” posted on medRxiv 16 June.
Mapping neurodevelopmental diversity in executive function | #medRxiv https://t.co/R3DTMQrOPJ pic.twitter.com/xGQIvP2BLx
— Marc L Seal (@ParkvilleGeek) June 19, 2023
The Association for Child and Adolescent Mental Health shared a link to its podcast “Depression in autism and ADHD: What do we know?” posted 2 May.
Interested in learning more about #Neurodevelopmental disorders & comorbidity?
Listen now to this fantastic podcast with @Lucy_Livingston as she explores #Depression in #ADHD & #Autism, including the prevalence of ADHD & Autism. https://t.co/boijgSRkX1 pic.twitter.com/iL8GcYFJPL
— Association for Child & Adolescent Mental Health (@acamh) June 19, 2023
medRxiv linked to the preprint “Loss-of-function variants in CUL3 cause a syndromic neurodevelopmental disorder,” posted 16 June. Spectrum covered research on CUL3 in 2021 and 2019.
Loss-of-function variants in CUL3 cause a syndromic neurodevelopmental disorder https://t.co/e89RAbZpH8 #medRxiv
— medRxiv (@medrxivpreprint) June 16, 2023
Renato Polimanti of Yale School of Medicine tweeted about the upcoming World Congress of Psychiatric Genetics.
The #WCPG2023 symposia schedule is out! #SaveTheDate on OCT 11 for the symposium @ErinDunnScD, @michelnivard, @manuela_kouakou, @spaul1124, @DrAJespersen, @robbeewedow, and I organized to discuss the impact of socioeconomic factors on psychiatric genetic and epigenetics. @ISPGnet pic.twitter.com/78k1bA3YjG
— Renato Polimanti (@RenatoPolimanti) June 21, 2023
That’s it for this week’s Community Newsletter! If you have any suggestions for interesting social posts you saw in the autism research sphere, feel free to send an email to [email protected].
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Cite this article: https://doi.org/10.53053/CYYL9512
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