Mice engineered to carry a Rett syndrome mutation only in neurons are prone to an irregular heartbeat that can lead to sudden death, according to a study published 14 December in Science Translational Medicine.
Spectrum: Autism Research News
Efforts to ease the symptoms of autism are beginning to ramp up, with promising candidates in various stages of testing.
A new microscope allows researchers to capture the movement of tiny signal-receiving branches in the brains of adult mice at the nanoscale level. The results were published 3 February in Science.
Lithium alleviates the symptoms of fragile X syndrome in mice in part by normalizing protein synthesis in the brain, according to a study published 29 December in Neurobiology of Disease.
Two compounds that enhance the activity of BDNF, a protein needed for the growth of neurons, improve motor skills in mouse models of Rett syndrome and increase the mice’s lifespan.
Fluoxetine, an antidepressant marketed as Prozac, may alleviate repetitive behaviors in adults with autism, according to a study published 2 December in the American Journal of Psychiatry.
Clinicians and autism researchers should learn the early signs of autism and take into account an individual’s developmental trajectory, says Tony Charman.
A compound that boosts inhibitory signals in the brain could treat hyperactivity and excitability in mice that model fragile X syndrome, according to a study published 8 November in Developmental Neuroscience.