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Spectrum: Autism Research News

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The Brain

Charting the structure and function of the brain’s many circuits may unravel autism’s mysteries.

April 2022
Micrographs comparing mouse striatal neurons missing TSHZ3 and wildtype striatal neurons.

Two groups of neurons govern autism-like traits in model mice

by  /  15 April 2022

Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.

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Faulty inhibition foils long-term memory in Rett mice

by  /  11 April 2022

The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.

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Biases skew behavioral predictions from brain scans

by  /  6 April 2022

Models trained on datasets that lack racial and ethnic diversity perform less accurately on brain scans from Black Americans than their white counterparts.

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March 2022

Unfamiliar surroundings bring out autism-like behaviors, brain circuit changes in model mice

by  /  31 March 2022

A brain area called the tail of the striatum may account for the shift.

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New MRI probe illuminates neuronal interactions

by  /  30 March 2022

The calcium-sensing instrument translates neuronal activity into signals that can be detected via functional magnetic resonance imaging (fMRI).

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Neural network finds markers of autism, gender in brain scans

by  /  24 March 2022

Deep-learning algorithms can cut through some of the noise in brain imaging data collected across different sites.

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Switching neurons on and off to probe autism circuits

by  /  23 March 2022

A 3D optogenetics method can mimic natural rhythms of neural activity, rendering previously unanswerable questions amenable to inquiry — including questions about autism.

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New human neuron assays set stage for high-throughput autism drug screens

by  /  22 March 2022

The ability to conduct large-scale screening in human neurons could accelerate the discovery of autism treatments.

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Micrograph of neuron dendrite segments.

Maternal sleep apnea may contribute to autism-like traits in rats

by  /  18 March 2022

Pups born to mothers that experience low oxygen during sleep have overactive mTOR signaling, which has been linked to some forms of autism.

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Silenced X chromosome genes reawaken in new mouse model

by  /  3 March 2022

The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.

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