Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.

Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.

Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.

Such high expression levels may account for the condition’s sex bias, a new preprint suggests — but not everyone agrees with that logic.

Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.

A massive update to the MSSNG dataset gives qualified researchers ready access to explore autism’s genetic architecture on a cloud-based platform.

The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

A new method that merges tissue expansion, light-sheet microscopy and automated image segmentation can reconstruct neural circuits in about a week.

Faulty mTOR signaling, implicated in syndromic forms of autism, also hinders cells grown from people with idiopathic autism or autism-linked deletions on chromosome 16.