Shared brain structure, connectivity hint at autism subgroups
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
Charting the structure and function of the brain’s many circuits may unravel autism’s mysteries.
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
Brain cell clusters serve as drug screens and reveal connectivity differences for autism-linked conditions, two new models show.
UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.
Pagani used mouse models to connect autism etiologies to brain connectivity alterations and then found similar alterations in people with idiopathic forms of the condition.
New studies bolster the idea that zebrafish models can say something meaningful about social behavior in autism.
Brain scans of the hippocampus reveal autistic people who are at increased risk of cognitive problems as they get older.
The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.
Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Work in fruit flies has helped Paul decode a neurodevelopmental syndrome in children caused by rare de novo variants in the gene PPFIA3.