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Spectrum: Autism Research News

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The Brain

Charting the structure and function of the brain’s many circuits may unravel autism’s mysteries.

August 2023
Position heatmaps of mice performing a behavioral assay.

New test taps nose pokes as a proxy for social motivation in mice

by  /  10 August 2023

Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.

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A research image of the fly brain connectome

Full connectome of adult fruit fly completed, with help from citizen scientists

by  /  7 August 2023

The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.

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Still image from a video of a mouse maneuvering a robot around a maze while imaging tools capture neuronal activity in its cortex.

Robotic headgear records brain activity in moving mice

by  /  3 August 2023

The tool could help researchers study the neurobiology of natural behaviors, scientists say.

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July 2023
Research image of neurons.

Abundant motor proteins disrupt cries in FOXP2 mice

by ,  /  28 July 2023

Knocking down the gene that codes for the proteins normalizes the vocalizations.

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Illustration of half of a brain on the left and half of a heart on the right

Change of heart and mind: Autism’s ties to cardiac defects

by  /  21 July 2023

Children with congenital heart disease have an increased likelihood of autism. Why?

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Still image from a video of nerves being visualized in the body of a transparent mouse.

‘wildDISCO’ cocktail yields whole-body maps of mouse neurons and more

by  /  20 July 2023

A new technique used to create see-through rodents can help scientists analyze how the nervous system interacts with other body systems.

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A brown mouse looks away from a white mouse in a cage to its left.

‘VIP’ interneurons may drive autism traits in Dravet syndrome

by  /  19 July 2023

The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.

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Repurposed electronics lens spies neurons across entire mouse brain

by  /  14 July 2023

When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.

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Unknown isoform adds twist to theory of fragile X origins

by  /  11 July 2023

Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.

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Image of excitatory synapses in mouse brains.

Dispute erupts over role of sticky proteins in astrocytes

by  /  10 July 2023

But multiple independent researchers say they are not convinced by its results, which fail to confirm high-profile findings from 2017.

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