A new method that merges tissue expansion, light-sheet microscopy and automated image segmentation can reconstruct neural circuits in about a week.
Spectrum: Autism Research News
Charting the structure and function of the brain’s many circuits may unravel autism’s mysteries.
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
The model enables the study of autism-linked genes at the earliest stages of neural development.
Psychiatric genomics promises to shed light on the genetic basis of autism, but it’s vital to include Africa in this research, Iyegbe and Okewole say.
The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
Brain cell clusters serve as drug screens and reveal connectivity differences for autism-linked conditions, two new models show.
Pagani used mouse models to connect autism etiologies to brain connectivity alterations and then found similar alterations in people with idiopathic forms of the condition.