An experimental drug tamps down the expression of a gene duplicated in an autism-related condition and restores typical behavior in mice.
Autism’s core symptoms accompany a constellation of subtle signs that scientists are just beginning to unmask.
Rats missing UBE3A, the gene mutated in people with Angelman syndrome, squeak frequently but tend not to be responsive to the play and squeaks of other rats.
Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.
Delivery by cesarean section leads to subtle brain and behavioral alterations in mice, particularly those delivered prematurely.
Researchers have created an animated monkey avatar that makes realistic facial expressions — and that may yield insight into how autistic people interpret facial expressions.
A tiny chunk of the brain’s emotion enter, the amygdala, is enlarged in some autistic children; the larger this piece, the more anxious and depressed the child is likely to be.
Studying Smith-Magenis and Potocki-Lupski syndromes — two single-gene conditions in which people have trouble reading social cues — may boost our understanding of autism.
Not much is known about the connection between autism and Ehlers-Danlos syndrome, a condition that affects collagen. But preliminary work provides tantalizing clues.
A single seizure early in life leads to enduring behavioral problems, including diminished sociability, in mice.