Researchers have developed a tool that can predict whether DNA mutations that change a single base pair are likely to alter RNA splicing, a process that modifies the sequence of mRNA, the genetic message that codes for protein. The results were published 10 February in Bioinformatics.
Spectrum: Autism Research News
Science & Society
From funding decisions to scientific fraud, a wide range of societal factors shape autism research.
Prenatal genetic tests that can detect copy number variations, including those linked to autism, could raise tough questions for doctors and parents.
The odds of having a child with autism begin to rise at age 35 for both men and women, but that risk does not increase further when both parents are over 35, according to a large study published in the March issue of Annals of Epidemiology.
Researchers have developed functional magnetic imaging devices that are optimized to fit children’s heads, according to a study published in the December issue of Magnetic Resonance in Medicine. These tools increase the quality of the data and deter head motion, which research suggests can lead to spurious results.
The genetic risk factors for autism may also increase a person’s risk of developing ankylosing spondylitis, a form of arthritis of the spine, and decrease the risk of multiple sclerosis, according to a study published 13 December in Translational Psychiatry.
A commonly used flame retardant may lead to deficits in sociability, learning and memory in healthy female mice and those that model Rett syndrome, according to a study published 15 February in Human Molecular Genetics. The effects are different in Rett syndrome models compared with healthy mice, suggesting gene-environment interactions.