Two variants in a gene needed for the cell’s energy balance may protect the carriers from autism, according to an unpublished study presented today at the Society for Neuroscience meeting in Chicago.
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Mice missing FKBP12, a gene involved in a cancer pathway, show repetitive behavior and an impaired ability to socialize with other mice, and could be used to study autism, according to unpublished results presented at a poster session today at the Society for Neuroscience meeting.
Tracy Bale, associate professor of neuroscience at the University of Pennsylvania, talks about what she calls her “big soapbox issue”: the fallacious idea of a true animal model for a human psychiatric disease — and the pitfalls of over-interpreting rodent behavior.
Interested more in ideas than in dominating a crowded field, Michael Wigler decided to apply his expertise in cancer genetics to studying poorly understood features of autism.
A team of British researchers has garnered some of the first genetic evidence supporting their theory that sex hormones play a role in the development of autism.
Studying the relatively well-defined genetics of Williams syndrome may help unravel the poorly understood genetic and neurobiological roots of autism, researchers say.
Several new genetic variants associated with schizophrenia lie in regions important for immune function and associated with autism. This suggests that both disorders stem partly from abnormal activation of the immune system, say some researchers.
The brains of people with autism have structural abnormalities that disrupt normal connections between brain regions and impede the flow of information across the brain. That’s the conclusion of a 20-year-old theory supported by several new studies.
A common variant of a gene called CACNA1G — which makes a channel that helps regulate calcium flow between cells — may increase the risk of developing autism, according to research published in Molecular Psychiatry.