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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2010
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Brain ‘transcriptome’ reveals gene networks for autism

by  /  16 November 2010

Scientists have pinpointed two major gene networks relevant to autism by analyzing gene expression in brain tissue from individuals with the disorder. Researchers presented the data Sunday at the Society for Neuroscience annual meeting in San Diego.

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Stem cell assay reveals early development of Rett neurons

by  /  16 November 2010

Researchers have developed the first stem cell system that makes it possible to study the early development of neurons from people with Rett syndrome, a rare disorder on the autism spectrum.

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Decoding the exome points to new autism genes

by  /  16 November 2010

Sequencing the exomes — regions of the genome that code for proteins — of 18 individuals with autism has revealed new candidate genes for the disorder, researchers reported Sunday at the Society for Neuroscience annual meeting in San Diego.

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Rett gene needed to stabilize synaptic strength

by  /  16 November 2010

Blocking the expression of the MeCP2 gene decreases the number of synapses, the junctions between neurons. It also prevents synapses from scaling up their activity to make up for the loss, according to unpublished data shown yesterday at the Society for Neuroscience annual meeting in San Diego.

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Molecular mechanisms: Angelman gene linked to synapse formation

by  /  16 November 2010

UBE3A, a protein mutated in Angelman syndrome and autism, regulates communication between neurons in the brain, according to a study published 29 October in Cell.

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Common themes link etiology, treatment in autism

by  /  15 November 2010

Three themes — heterogeneity, phenotype, and trajectory — are beginning to emerge in diverse lines of inquiry into autism, according to speakers at a satellite symposium of the Society for Neuroscience annual meeting in San Diego.

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Mouse model of Timothy syndrome shows social deficits

by  /  15 November 2010

Mice bearing the genetic defect that causes Timothy syndrome show many autism-like behaviors, and may also have enhanced cognitive abilities like those seen in a small number of people with autism, suggests a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.

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Video: Unusual animals lead to interesting results

by  /  15 November 2010

A variety of animal models can help researchers better address human-specific questions in neurological disorders such as autism, says Theresa Lee, who has used exotic animal models to study circadian rhythms.

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Mouse models gene-environment interactions in autism

by  /  15 November 2010

The gene-environment interactions that are thought to contribute to many cases of autism can now be explored in a mouse model, according to a poster presented Sunday at the Society for Neuroscience annual meeting in San Diego.

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Genetics: Two families link new gene to autism

by  /  15 November 2010

Researchers have narrowed down a genetic region associated with autism to one protein, cadherin 8, that helps bind cells together, according to a study published online in October in the Journal of Medical Genetics. This is the first time CDH8, the gene that encodes this protein, has been associated with autism.

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