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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2010
News

Asocial BTBR strain is “autistic mouse,” researcher claims

by  /  17 November 2010

An asocial inbred mouse strain called BTBR may show behaviors associated with autism, such as avoiding eye gaze and forming an attachment to objects, researchers reported Monday at the Society for Neuroscience annual meeting in San Diego.

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Connections between language areas impaired in autism

by  /  17 November 2010

Important language areas in the brain don’t show the expected patterns of connectivity when people with autism listen to speech, suggests a poster presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Autism symptoms more severe in younger siblings

by  /  17 November 2010

In families with more than one child diagnosed with autism, younger siblings appear to be more severely affected by the disorder, according to new data presented Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Genetics: Lower verbal intelligence in autism is inherited

by  /  17 November 2010

Better performance on intelligence tests that measure spatial rather than verbal ability is inherited in people with autism, according to a paper published online in October in Human Genetics.

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Allen Institute charts gene expression in brain development

by  /  17 November 2010

The Allen Institute for Brain Science has released whole-genome expression data from one-and-a-half adult human brains, and is gathering information from samples at different stages of development, from four weeks after conception to adulthood. The data were described at poster sessions Saturday and Tuesday at the Society for Neuroscience annual meeting in San Diego.

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Tuberous sclerosis mice have fewer synaptic proteins

by  /  17 November 2010

A study of mice with tuberous sclerosis — a single-gene disorder that is related to autism — suggests that most forms of autism share a common feature: an imbalance of proteins at the synapse, the junction between neurons. The work was presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Brains of children with autism change as they grow up

by  /  17 November 2010

The brains of children with autism show differences in gene expression compared with those of healthy controls, especially in genes that control cell growth. Adults with autism also have aberrant gene expression, but in different pathways, researchers reported Sunday at the Society for Neuroscience annual meeting in San Diego.

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People with autism assign negative emotions to photos

by  /  16 November 2010

People with autism take longer to decide whether emotionally ambiguous facial expressions are positive or negative — and are more likely than healthy controls to choose the latter, say researchers who reported their results in a poster Sunday at the Society for Neuroscience annual meeting in San Diego in San Diego.

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Large postmortem brain study traces spine shapes

by  /  16 November 2010

The brains of people with autism have abnormally dense and stubby dendritic spines, the neuronal projections that receive electrical signals, according to data presented Monday at the Society for Neuroscience annual meeting in San Diego.

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Video: Drosophila model of fragile X syndrome bears fruit

by  /  16 November 2010

The fruit fly is a good model for some of the cognitive defects in fragile X syndrome — but researchers sometimes find themselves having to defend their choice.

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