An autism-associated gene variant of glyoxalase 1, or GLO1, leads to the buildup of a compound that is toxic to neurons, according to a study published 12 April in Autism Research.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Family support groups may be the best messengers to convey the urgent need for brain tissue in autism research, say scientists struggling with inadequate resources.
Two rare, unlikely and inherited mutations in the same gene may together have contributed to a case of autism, according to a study published 23 March in Molecular Psychiatry. The results suggest that the gene, DIAPH3, is a new candidate for autism risk.
Mutations in a protein called GRIP1, important for the function of synapses — the junctions between neurons — may contribute to social deficits in autism, researchers reported 22 March in the Proceedings of the National Academy of Sciences.
At 12 months of age, infant siblings of children with autism have a brain response to unfamiliar faces that is characteristic of typical children at a younger age, according to a study published 26 March in Brain Topography. This developmental delay could be used as an early biomarker for autism.
Mice missing the autism candidate gene MET have connections in the cortex that are twice as strong as those in controls, according to a new study.
A mysterious cluster of sudden deaths among young people who had a genetic syndrome is drawing attention to the high rate of unexplained deaths in individuals with autism and epilepsy.
Researchers have taken skin cells from individuals with schizophrenia, bathed them in chemical cocktails and coaxed them to develop into neurons, according to a paper published 13 April in Nature.