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Spectrum: Autism Research News

TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

February 2011

Genetic background alters behavior of fragile X mice

by  /  21 February 2011

Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.

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Genetics: Centrosome gene linked to autism

by  /  18 February 2011

Rare mutations in TSGA14, a component of the centrosome — which is required for the generation of new neurons — may be associated with autism, according to a study published in January in the American Journal of Medical Genetics.

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Molecular mechanisms: Mice model milder form of fragile X

by  /  16 February 2011

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.

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Families hint at diverse effects of chromosome 16p deletion

by  /  14 February 2011

Two new studies of families carrying glitches on a region of chromosome 16, which has been strongly associated with autism, reveal the wide range of effects caused by the variant and narrow the list of possible culprit genes.

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Search for Asperger syndrome genes unearths links to autism

by  /  10 February 2011

A genome-wide association study has identified risk factors for Asperger syndrome, some of which overlap with chromosomal regions implicated in autism, according to a study in the December issue of Autism Research.

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Molecular mechanisms: Men with fragile X have enlarged brains

by  /  9 February 2011

Men with fragile X syndrome have larger brains overall than controls do, but less matter in regions involved in language and social interaction.

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Lost in translation

by  /  8 February 2011

The National Institutes of Health is adding a new $1 billion institute for early-stage drug development. But the agency’s plan to fund it by closing the National Center for Research Resources is causing some consternation.

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Clinical research: Study questions symptoms of Angelman syndrome

by  /  8 February 2011

One of the first large-scale, ongoing studies documenting the symptoms of Angelman syndrome — a neurological disorder with features similar to autism — is calling into question some of the so-called characteristic symptoms of the syndrome.

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Future shock

by  /  2 February 2011

As genetic testing becomes routine, people are likely to face difficult choices about parenthood.

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Cognition and behavior: Anxiety in speech linked to autism

by  /  2 February 2011

A rare childhood speech disorder related to social anxiety is associated with a gene linked to autism, according to a study published in December in Biological Psychiatry. The results suggest that the two disorders share a common mechanism.

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