Two autism-associated genes that function at the synapse, the junction between neurons, are associated with severe intellectual disability, according to a study published 9 August in BMC Medical Genetics.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Collapsing the three core domains of autism — impairments in social interaction, communication deficits, and repetitive and restricted behaviors — into two makes no difference in the accuracy of diagnosis, according to a statistical analysis published 20 August in the Journal of Autism and Developmental Disorders.
A compound that shows promise as a treatment for fragile X syndrome alleviates repetitive behaviors in mice, but unexpectedly makes them less social.
Individuals with a duplication of a chromosomal region associated with autism and intellectual disability are at higher risk for low birth weight, restricted eating leading to extreme thinness, and smaller-than-average head size.
Healthy parents of children with autism have an atypical brain response to sound frequency changes that mimics the response of individuals with the disorder.
Harmful spontaneous mutations may account for up to half the cases of non-inherited schizophrenia.
BTBR mice, which are less social than the typical B6 mice, have an elevated immune response in their brains and blood compared with those mice, according to a study published 20 July in PLoS ONE. Hybrids of BTBR and B6 mice have intermediate levels of immune molecules.