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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

February 2011
News / Profiles

Matthew State: Bridging the gap between bench and bedside

by  /  24 February 2011

Matthew State is both a dedicated clinician and a world-class geneticist, but his diplomatic style is a relic of his former adventures in politics.

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News

Genetics: Study reexamines role of 16p11.2 in autism

by  /  23 February 2011

Duplication or deletion of 16p11.2 — a much-studied chromosomal region with a strong association with autism — is present in 0.76 percent of people with the disorder, according to a meta-analysis published February in Genetics in Medicine.

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News / Toolbox

Database organizes multiple mouse models

by  /  23 February 2011

A genetic database of autism genes, called Autism Database, or AutDB, details curated information for more than 200 mouse models of autism, according to a report in the January BMC Genomics.

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News

Cognition and behavior: Serotonin pathway affects mouse behavior

by  /  22 February 2011

Mice that lack the gene for integrin β3, or ITGB3 — which regulates the levels of serotonin in the blood — groom themselves frequently and show less interest in stranger mice compared with controls, according to a study published in February in Autism Research as part of a special issue on mouse models in autism.

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News

Genetic background alters behavior of fragile X mice

by  /  21 February 2011

Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.

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News

Genetics: Centrosome gene linked to autism

by  /  18 February 2011

Rare mutations in TSGA14, a component of the centrosome — which is required for the generation of new neurons — may be associated with autism, according to a study published in January in the American Journal of Medical Genetics.

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News

Molecular mechanisms: Mice model milder form of fragile X

by  /  16 February 2011

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.

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News

Families hint at diverse effects of chromosome 16p deletion

by  /  14 February 2011

Two new studies of families carrying glitches on a region of chromosome 16, which has been strongly associated with autism, reveal the wide range of effects caused by the variant and narrow the list of possible culprit genes.

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News

Search for Asperger syndrome genes unearths links to autism

by  /  10 February 2011

A genome-wide association study has identified risk factors for Asperger syndrome, some of which overlap with chromosomal regions implicated in autism, according to a study in the December issue of Autism Research.

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News

Molecular mechanisms: Men with fragile X have enlarged brains

by  /  9 February 2011

Men with fragile X syndrome have larger brains overall than controls do, but less matter in regions involved in language and social interaction.

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