TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

January 2008
Opinion / Reviews

Autism and the arts: “Lucy” captures disorder’s complexity

by  /  28 January 2008

Itʼs not often that movies, books and plays represent science accurately, or with a true and empathetic understanding of its complexity.

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News

Changes in chromosome 16 firmly linked to autism

by  /  9 January 2008

In a paper published today in The New England Journal of Medicine, researchers have identified a segment containing 25 genes on chromosome 16 that was deleted or duplicated in roughly one percent of children with autism.

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Opinion / Viewpoint

The 1999 Rett syndrome paper

by  /  3 January 2008

Huda Zoghbi and her colleagues painstakingly sequenced the candidate genes for Rett syndrome, culminating in the 1999 Nature Genetics report that pinpointed six de novo mutations in the MeCP2 gene as the cause of the disorder.

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News

Fragile X symptoms reversed in mice

by  /  3 January 2008

Fragile X syndrome is a rare and devastating condition, and a risk factor for autism. New research suggesting the condition is reversible in mice has some wondering whether treatments for the syndrome ― and for some forms of autism ― could be on the horizon.

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News / Profiles

Josh Huang: In dogged pursuit of autism’s off switch

by  /  3 January 2008

In 1982, Josh Huang was an impressionable young biology undergraduate at Shanghaiʼs FuDan University. Like some of his fellow Chinese students, he knew he wanted to be a neuroscientist, but with limited access to scientific journals, had no idea which big questions were then at the forefront of research.

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December 2007
Opinion / Viewpoint

Leo Kanner’s 1943 paper on autism

by  /  7 December 2007

Donald T. was not like other 5-year-old boys. Leo Kanner knew that the moment he read the 33-page letter from Donaldʼs father that described the boy in obsessive detail as “happiest when he was alone… drawing into a shell and living within himself… oblivious to everything around him.”

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News

Maternal flu linked to autism

by  /  7 December 2007

Having the flu during pregnancy can be unpleasant and exhausting. But can it affect fetal brain development and cause autism-like disorders? Intriguing new research says yes ― at least in mice.

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News / Profiles

Gordon Fishell: Oracle’s gift to autism

by  /  7 December 2007

Along with answering fundamental questions about mammalian brain organization, watching interneurons’ “handshake” with other brain cells is the key to understanding autism, says Gordon Fishell.

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News / Profiles

Aravinda Chakravarti: Not everything we do is biology

by  /  7 December 2007

Stylianos Antonarakis still vividly remembers the thorny statistical problem that had vexed him for several months in 1982. Antonarakis, then a postdoctoral fellow at Johns Hopkins University, had turned to his colleagues at Hopkins, but none of them had been able to solve the problem.

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