Blocking a chemical messenger — a much-touted approach to treating fragile X syndrome — is unlikely to completely reverse symptoms of the disorder, according to a provocative new study. The results, published in May in Behavioural Brain Research, show only modest behavioral improvements with the approach.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
Individuals with autism do not have so-called ‘eagle-eyed’ vision as reported by some studies, according to research published 10 June in the Journal of Autism and Developmental Disorders.
A new study of twins proposes the controversial claim that environmental influences during early development are just as, if not more, important than genetics. But the findings are not substantially different from those of previous twin studies, however, and some experts are critical of the study’s statistics.
Children who express a subset of genes — including one located in the autism-associated chromosomal region 16p11.2 — at higher or lower levels than normal benefit from treatment with the antipsychotic drug risperidone, according to a study published 7 June in the Pharmacogenomics Journal.
A new computer algorithm has identified the gene responsible for a newly discovered human disease, researchers report this week in The American Journal of Human Genetics. Unlike traditional methods, the algorithm takes into account both the odds of a particular genetic variant being associated with the disorder and the variant’s effect on protein function.
Neurexin 1, an autism-associated protein that functions at the junctions between neurons, has a flexible hinge that can toggle the protein between a more compact or a more accessible shape, a crystal structure published 8 June in Structure reveals.
FOXP2, a gene tied to autism and language disorders, is needed for proper wiring of the developing brain, according to a study published 7 July in PLoS Genetics.
A multi-site collaborative venture between the U.S., Canada and Europe has created nearly 17,000 mouse embryonic stem cell lines, each lacking one of the genes in the mouse genome.