TOPIC

Diagnosis

Diagnosing autism is an evolving science but a crucial first step to understanding the disorder.

July 2010
News

Brain curvature distinguishes Asperger syndrome from autism

by  /  16 July 2010

A region of the brain that controls language is more extensively curved in children with autism than in those with Asperger syndrome, according to a study published in the Journal of Child Neurology. The findings offer preliminary biological evidence that Asperger syndrome, a disorder on the autism spectrum, is distinct from high-functioning autism.

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News

Chromosome 7 segment gives clues to complex social behavior

by  /  12 July 2010

Individuals carrying an extra copy of the genetic region that’s missing in Williams syndrome — which causes mental retardation and a hyper-friendly personality — have language impairments and other autism-like social difficulties, according to a wave of new research on this duplication syndrome.

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News

Deep sequencing questions role of imprinted genes in autism

by  /  8 July 2010

The mouse brain has more than 1,300 regions for which the copy from one parent is expressed more often than the one from the other parent, according to two studies published today in Science. These so-called imprinted genes have been proposed to cause some cases of autism, but the researchers say their findings do not support that theory.

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June 2010
News

Pharma companies set their sights on autism

by  /  29 June 2010

A decade of research on the biology of autism, combined with a steady rise in diagnoses, has finally piqued the pharmaceutical industry’s interest in developing drugs for the disorder. Preliminary data from one small clinical trial already show positive results, and results from several others are expected early this summer.

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Opinion

Simple pathway

by  /  24 June 2010

A study of a rare form of epilepsy found in Amish groups adds heft to the idea that mTOR — a much-studied hub in a massive network of brain cell proteins — is an important biochemical player in autism.

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News

Autism marked by copy number changes in coding regions

by  /  11 June 2010

People with autism harbor more copy number variants (CNVs) — deletions or duplications of large chunks of DNA — compared with controls, but only in the protein-coding regions of the genome, researchers reported Wednesday in Nature. The study also pinpointed more than 100 new risk genes for autism.

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May 2010
News

Microarray analysis deemed best genetic test for autism

by  /  28 May 2010

Chromosomal microarray analysis, which screens the entire genome for tiny blips in the sequence, should be the first genetic test performed when diagnosing autism, says a consortium of clinical geneticists. The recommendation comes on the heels of a study that found the test is three times more effective at spotting autism variants than are standard clinical methods.

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News

Gene expression pattern could pinpoint autism

by  /  25 May 2010

Researchers can reliably identify individuals with autism by looking at the expression pattern of a set of genes in cultured blood cells, according to a poster presented Friday at the IMFAR 2010 conference in Philadelphia.

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News

Geometric gaze

by  /  20 May 2010

Some children with autism prefer to look at geometric patterns rather than at ‘social’ images of other children — and this tendency is obvious as early as 14 months of age, according to a poster presented today at IMFAR 2010 in Philadelphia.

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News

Williams syndrome precludes racial bias, study finds

by  /  20 May 2010

Children with Williams syndrome — a rare genetic disorder that leads to mental retardation and overt friendliness — hold stereotypes based on gender, but not race, according to a report published in Current Biology. Because those with Williams syndrome don’t have social fear, the study suggests racial stereotypes are based partly on fear.

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