Diagnosis

Mice lacking one copy of a gene associated with Williams syndrome share the hyper-sociability of people with the disorder, according to a paper published online 3 December in Autism Research.

Teenagers with autism are less efficient at rapidly shifting their eye gaze — an indicator of motor ability — compared with either typically developing controls or adolescents with Asperger syndrome, according to a study published in November in Cerebellum.

Most studies define high-functioning children as those with an IQ above 70 or 80, but this is problematic for a number of reasons, say some scientists. The assumption underlying the use of high IQ as a synonym for high functioning is suspect because social and communicative abilities may have a far greater impact on an individual’s daily interactions.

Spontaneous mutations that change a single DNA base account for a large proportion of cases of unexplained mental retardation, according to a study published in the December Nature Genetics.

Toddlers with autism take longer to build their vocabulary than do those who have only language impairment, according to a study published online in November. When matched by vocabulary level, however, the two groups use the same types of words and have the same grammatical skills.

Two independent groups have created mice that have deletions or duplications in a large section of chromosome 16. Each team has produced an animal with a different set of features, some of which — such as large head size and repetitive behaviors — are reminiscent of people with autism.

Individuals with a deletion in the 16p11.2 chromosomal region — which has been linked to autism in several studies — show features of autism spectrum disorders including language delay, according to a study published in October.