Tag: zebrafish

March 2015
News

Studies trace far-reaching effects of single autism gene

by  /  19 March 2015

Scientists peel back the layers of genetic complexity in autism, starting with the master regulator CHD8.
 

5 Comments
February 2015
News

Study downgrades autism gene’s effects to rare glitches

by  /  16 February 2015

After eight years of prominence as an autism risk gene, a new analysis significantly brings down CNTNAP2’s importance in the disorder: According to the study, rare mutations in a single copy of the gene are unlikely to cause autism. 

11 Comments
December 2014
Features / Special Reports / 2014 Year in review

Tomorrow’s tools

22 December 2014

For 2014, rather than compile the ‘top tools and techniques’ — a list certain to include CRISPR and other technical tricks detailed in our weekly Toolboxes — we asked researchers to dream up the next big tool in autism research. Their wishes range from protein sequencers to scanners that can capture brain activity during daily activities.

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November 2014
News

Calcium sensor leaves permanent mark in activated neurons

by  /  17 November 2014

Researchers have engineered a fluorescent sensor that irreversibly switches from green to red when a neuron fires, thereby serving as a permanent mark of neuronal activation. They described the unpublished work Monday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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October 2014
News

Autism-linked deletion sparks symptoms via many genes

by  /  23 October 2014

Deletion or duplication of 16p11.2, a chromosomal region linked to autism, may trigger symptoms via the interactions of genes both within and outside the region at a key point in development. Researchers presented these preliminary results Sunday at the 2014 American Society of Human Genetics Annual Meeting in San Diego.

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August 2014
News

‘Thunder’ promises lightning-fast analysis of big brain data

by  /  14 August 2014

Researchers have developed a set of software tools called Thunder that can find meaningful patterns in large-scale data on brain activity.

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July 2014
News

Cluster of symptoms reveals gene’s link to autism subtype

by  /  3 July 2014

CHD8, a gene that regulates the structure of DNA, is the closest thing so far to an ‘autism gene,’ suggests a study published today in Cell. People with mutations in this gene all have the same cluster of symptoms, including autism.

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Opinion / Q&A

Questions for Nicholas Katsanis: Fishing for autism genes

by  /  1 July 2014

Cell biologist Nicholas Katsanis explains why zebrafish have been key in studying a chromosomal region linked to autism.

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June 2014
News / Toolbox

Sophisticated camera captures all firing neurons

by  /  18 June 2014

A new imaging technique can capture the activity of every neuron in a zebrafish larva or a roundworm. Researchers described the method, which is at least ten times faster than others, in Nature Methods.

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News / Toolbox

Light corrections illuminate a path into fish brains

by  /  11 June 2014

Taking a page from astronomy’s playbook, researchers have developed a way to take dramatically clear pictures of the inner workings of a zebrafish brain.

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