Tag: UBE3A

October 2012
News

Study implicates ‘pleasure circuit’ in Angelman syndrome

by  /  18 October 2012

Mice that model Angelman syndrome, an autism-related disorder, are more motivated to earn rewards than controls are, according to unpublished results presented Wednesday at the 2012 Society for Neuroscience annual meeting in New Orleans.

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News

Molecular mechanisms: Angelman region affects serotonin

by  /  12 October 2012

Mice that model Angelman syndrome or have a duplication of the 15q11-13 chromosomal region have aberrant brain levels of the chemical messenger serotonin, according to a study published 16 August in PLoS One.

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August 2012
News

Researchers home in on dosage effects of 15q11-13 region

by  /  13 August 2012

Researchers are beginning to tease apart how dosage of genes within the 15q11-13 chromosomal region contributes to autism symptoms.

2 Comments
News

Nonprofit rallies funds to create autism-related mouse model

by  /  9 August 2012

Concerned by researchers’ lack of access to a valuable mouse model of autism, a nonprofit advocacy group is dedicating a chunk of its limited resources to the creation of a freely available version.

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July 2012
Opinion

Gene therapy

by  /  20 July 2012

Delicate dosage issues are just one complication of developing gene therapy for neurodevelopmental disorders.

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News

Angelman mice show impaired inhibition of brain signals

by  /  2 July 2012

Mice lacking a functional copy of UBE3A, the gene missing or mutated in people with the rare developmental disorder Angelman syndrome, show less inhibitory activity than controls do, according to research published 7 June in Neuron.

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May 2012
Opinion

Rinse and repeat

by  /  22 May 2012

Researchers typically use only one ‘cohort,’ a group of about three dozen mice, for a given set of experiments. When others repeat the experiments with a different set of animals, sometimes the results hold up, and sometimes they don’t.

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April 2012
News

Molecular mechanisms: Stress pathway dysregulated in autism

by  /  27 April 2012

Two studies report abnormalities in the system that mediates the body’s response to stress in two mouse models of autism-related diseases: Angelman syndrome and Rett syndrome. The results were published in the April issue of Human Molecular Genetics.

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January 2012
News

Funding fears prevent researchers from sharing their mice

by  /  9 January 2012

Despite funders’ requirements to share mouse models after publication, many researchers hoard the animals for the good of their labs — and that could have an adverse effect on the field as a whole.

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December 2011
News

Clinical research: Cancer drug could treat Angelman syndrome

by  /  21 December 2011

A cancer drug shows promise as a treatment for Angelman syndrome, according to a study published today in Nature.

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