Tag: UBE3A

August 2015
News

Hyperactive protein points to possible autism treatment

by  /  10 August 2015

A mutation that boosts the activity of the autism risk gene UBE3A may cause neurons to form too many connections, disrupting brain development. Some people with autism have extra copies of the gene, so the findings, published last week in Cell, add to evidence implicating UBE3A in autism.

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July 2015
News

Dispatches from the 2015 Dup15q Alliance Scientific Meeting

by  /  30 July 2015

These short reports from our reporter, Nicholette Zeliadt, give you the inside scoop on developments at the 2015 Dup15q Alliance Scientific Meeting.

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May 2015
News

Early treatment is key for children with Angelman syndrome

by  /  8 May 2015

Fixing the gene that’s faulty in Angelman syndrome ameliorates anxiety and motor deficits in a mouse model of the disorder, but only if done early in life.

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April 2015
News / Toolbox

Tiny square rafts help neurons thrive in lab

by  /  8 April 2015

A convoy of miniature plastic rafts boosts the survival of lab-grown neurons, using a new method that could help autism researchers easily grow many thousands of cells at once.

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January 2015
News

Surplus of synapses may stunt motor skills in autism

by  /  5 January 2015

An overabundance of neuronal connections in the brains of people with autism may contribute to the motor impairments associated with the disorder.
 

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December 2014
News

Snippets of RNA may reverse symptoms of Angelman syndrome

by  /  4 December 2014

Small pieces of RNA restore the expression of a key gene missing in Angelman syndrome and offer the promise of a highly specific cure, researchers reported Monday in Nature.

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November 2014
News

Feisty mice may reveal autism gene’s link to aggression

by  /  20 November 2014

Varying the number of copies of a single autism-linked gene modulates social behavior and aggression in mice, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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October 2014
News

Seizures trigger autism-like behaviors in mice

by  /  23 October 2014

Mice with an extra copy of the autism-linked gene UBE3A show abnormal social behavior after experiencing recurrent seizures. The findings, presented Tuesday at the Autism Consortium Research Symposium in Boston, provide one possible explanation for why seizures and autism often go hand in hand.

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September 2014
News

Rousing silenced X chromosome may treat Rett syndrome

by  /  29 September 2014

Drugs that activate the silent copy of the X chromosome in women may be able to undo the damage from mutations in genes located there. The study, published 2 September in Proceedings of the National Academy of Sciences, offers hope for treating Rett syndrome and other disorders linked to the chromosome.

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Opinion / Q&A

Questions for Lawrence Reiter: Extracting clues from teeth

by  /  9 September 2014

Neurologist Lawrence Reiter is growing neurons from the discarded teeth of children with neurological syndromes. Here he describes how dental pulp may help researchers find the genes and pathways that underlie autism symptoms.

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