Tag: UBE3A

April 2015
News / Toolbox

Tiny square rafts help neurons thrive in lab

by  /  8 April 2015

A convoy of miniature plastic rafts boosts the survival of lab-grown neurons, using a new method that could help autism researchers easily grow many thousands of cells at once.

January 2015

Surplus of synapses may stunt motor skills in autism

by  /  5 January 2015

An overabundance of neuronal connections in the brains of people with autism may contribute to the motor impairments associated with the disorder.

November 2014

Feisty mice may reveal autism gene’s link to aggression

by  /  20 November 2014

Varying the number of copies of a single autism-linked gene modulates social behavior and aggression in mice, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

1 Comment
October 2014

Seizures trigger autism-like behaviors in mice

by  /  23 October 2014

Mice with an extra copy of the autism-linked gene UBE3A show abnormal social behavior after experiencing recurrent seizures. The findings, presented Tuesday at the Autism Consortium Research Symposium in Boston, provide one possible explanation for why seizures and autism often go hand in hand.

September 2014

Rousing silenced X chromosome may treat Rett syndrome

by  /  29 September 2014

Drugs that activate the silent copy of the X chromosome in women may be able to undo the damage from mutations in genes located there. The study, published 2 September in Proceedings of the National Academy of Sciences, offers hope for treating Rett syndrome and other disorders linked to the chromosome.

Opinion / Q&A

Questions for Lawrence Reiter: Extracting clues from teeth

by  /  9 September 2014

Neurologist Lawrence Reiter is growing neurons from the discarded teeth of children with neurological syndromes. Here he describes how dental pulp may help researchers find the genes and pathways that underlie autism symptoms.

August 2014

Treatments for Angelman syndrome face critical window

by  /  15 August 2014

Drugs designed to treat Angelman syndrome may alleviate symptoms only if given during a ‘critical period’ early in development. That’s the upshot from unpublished results presented yesterday at a conference in Boston.

May 2014

Clinical research: Angelman gene variants alter symptoms

by  /  30 May 2014

The nature of the mutation that leads to Angelman syndrome — a disorder characterized by speech impairment and developmental delays — affects the disorder’s presentation, reports a study published 19 March in Research in Developmental Disabilities.

March 2014
Opinion / Viewpoint

No longer junk: Role of long noncoding RNAs in autism risk

by ,  /  4 March 2014

Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur.

February 2014

Genetics: Chinese population study identifies new autism gene

by  /  11 February 2014

Mutations in TRIM33, a protein that is part of the cell’s cleanup crew, may up the risk for autism, according to a study published 5 November in Molecular Psychiatry.