Tag: UBE3A

December 2017
Week of DecemberDec
4th
2017
News / Spotted

Pruning protein; cultural connection; cannabis consent and more

by  /  8 December 2017

A pruning protein reshapes neurons, culture should be a consideration in trials of autism treatments, and another U.S. state adds autism to the list of indications for medical cannabis.

1 Comment
November 2017
Mice that lack UBE3A only in their inhibitory neurons are particularly susceptible to seizures.
News

Gene therapy technique prevents seizures in Angelman mice

by  /  12 November 2017

Introducing the gene UBE3A into neurons that dampen brain activity prevents seizures in a mouse model of Angelman syndrome.

0 Comments
July 2017
News

Anxiety, seizures mark mice with extra copy of autism gene

by  /  31 July 2017

Mice with an extra copy of UBE3A, a gene linked to autism, have learning problems and anxiety, and are prone to seizures and fine-motor problems.

0 Comments
May 2017
News

Brain’s reward region may drive social problems in autism

by  /  17 May 2017

Having too many copies of an autism gene called UBE3A mutes a brain region that may mediate the satisfaction a person derives from social interactions.

2 Comments
November 2016
Mouse brain hippocampus
News

New mice expose consequences of key autism gene

by  /  17 November 2016

Mice with an extra copy of the autism risk gene UBE3A have cognitive deficits and anxiety, but do not show any core features of the condition.

0 Comments
August 2016
News

Motor troubles in Angelman may stem from nerve fiber anomaly

by  /  1 August 2016

Unusually thin nerve fibers in the brain may underlie the motor difficulties seen in children with Angelman syndrome, an autism-related condition.

0 Comments
July 2016
News

Tricks to treat Angelman syndrome may lie in ‘clock cells’

by  /  4 July 2016

A newly discovered phenomenon in cells that regulate the sleep-wake cycle may provide clues for how to treat two autism-related conditions.

0 Comments
April 2016
News

Subset of neurons may spark seizures in Angelman syndrome

by  /  25 April 2016

Mutations in a set of neurons that dampen brain activity may be the source of seizures in an autism-related syndrome.

1 Comment
February 2016
News

Mouse study offers promise of reversing autism symptoms

by  /  19 February 2016

Treatments for autism might be effective even after the brain is fully formed.

45 Comments
October 2015
News

For autism mouse models, gender matters

by  /  22 October 2015

The mutation that leads to Angelman syndrome may affect the brains of female mice more severely than those of male mice.

0 Comments