Mice carrying any one of five autism-linked mutations struggle to associate a flash of light with an irritating puff of air. The findings suggest that the mice have trouble integrating information from multiple senses — a skill governed by the cerebellum.
Treatments for fragile X syndrome may be more successful if they block direct targets of the key missing protein, says Eric Klann.
A treatment that targets the genetic defect in tuberous sclerosis prevents autism-like symptoms in mice at 6 weeks of age — the mouse equivalent of adolescence. Researchers presented the unpublished results yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
Neurologist Lawrence Reiter is growing neurons from the discarded teeth of children with neurological syndromes. Here he describes how dental pulp may help researchers find the genes and pathways that underlie autism symptoms.
The brains of children with autism do not prune unneeded connections between neurons as they age, leaving them with too many of these neuronal links, according to a study published 21 August in Neuron.
Children who have both the rare genetic disorder tuberous sclerosis complex and autism show a gradual drop in nonverbal intelligence between 1 and 3 years of age, according to research published 11 June in Neurology.
There are no available medications for treating autism’s core symptoms, but there are several candidates in clinical trials. Jeremy Veenstra-VanderWeele describes the factors researchers must take into account when developing drugs for the disorder.
Autism, schizophrenia and intellectual disability share underlying deficits in pathways that regulate how the brain encodes new experiences, says Jason Shepherd.
Two autism-related disorders share disruptions in immune pathways despite major differences in the individual genes affected, according to a study published 24 February in Molecular Autism.
Thought until recently to only coordinate motor skills, the cerebellum is involved in diverse cognitive functions such as language and social interaction, and may play a role in autism, says Emanuel DiCicco-Bloom.