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Spectrum: Autism Research News

Tag: tuberous sclerosis

March 2022

Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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November 2021
Dr. Shafali Jeste portrait with a vibrant fuschia background.

Shafali Jeste: Early autism meets its match

by  /  30 November 2021

Shafali Jeste has spent the bulk of her scientific career searching for biological markers of autism. Her goal: to improve lives through early diagnosis and speedy testing of therapies.

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October 2021

Deep-learning model may accurately predict autism diagnosis

by  /  28 October 2021

The algorithm estimates a child’s likelihood of having autism from patterns of co-occurring conditions in electronic health records, outperforming a widely used screening test.

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September 2021
A concerned man holds his toddler close

Severe infection may raise odds of autism in some children

by  /  17 September 2021

Mock viral infections impair social memory in mice with a mutation tied to autism, and autistic boys are more likely than their non-autistic peers to have had serious infections early in life.

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August 2021

Molecular overlap links tuberous sclerosis, fragile X

by  /  16 August 2021

Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.

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June 2021
Micrograph of two developing axons, one with one copy of TSC2 gene and the other with two copies.

Disrupted cell skeletons may explain brain wiring changes in autism-linked condition

by  /  28 June 2021

Neuronal axons ignore guidance cues after a mutation in the gene TSC2 disrupts signaling through RhoA, a protein regulated by many autism-linked genes.

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October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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August 2020
Micrograph of neurons in mouse brain.

Inside scientists’ quest to map, modulate social circuits in autism

by  /  17 August 2020

A growing number of studies are revealing circuits that may underlie social challenges in autism — and how to fine-tune them.

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March 2020

Telehealth may enable remote participation in autism trials

by  /  3 March 2020

Some families do not have the financial ability or time to participate in clinical trials for autism. New technologies may enable them to participate from their homes.

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November 2019

Mouse study reveals overlooked target for autism therapies

by  /  20 November 2019

Blocking one form of an enzyme implicated in autism eases unusual behaviors and seizures in mice missing a top autism gene.

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