Tag: TSC1

September 2017
Illustration of Protein factories at neuronal junctions
Opinion / Viewpoint

Protein factories at neuronal junctions take center stage in autism

by ,  /  12 September 2017

Some genes linked to autism regulate the production of proteins at neuronal junctions, suggesting that disrupted protein synthesis contributes to the condition.

January 2017
Opinion / Viewpoint

Exploring the hidden world of inhibitory brain signals

by ,  /  24 January 2017

Scientists have discovered more than 100 new proteins at junctions in the brain that dampen neuronal activity.

Features / Deep Dive

The curious connection between autism and cancer

by  /  11 January 2017

A surprising number of genes associated with autism also have links to cancer. Does that mean cancer drugs can treat autism?

August 2015

Blinking mice bolster cerebellum’s link to autism

by  /  14 August 2015

Mice carrying any one of five autism-linked mutations struggle to associate a flash of light with an irritating puff of air. The findings suggest that the mice have trouble integrating information from multiple senses — a skill governed by the cerebellum.

November 2014

Treatment prevents autism-like symptoms in ‘teenage’ mice

by  /  16 November 2014

A treatment that targets the genetic defect in tuberous sclerosis prevents autism-like symptoms in mice at 6 weeks of age — the mouse equivalent of adolescence. Researchers presented the unpublished results yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

1 Comment
September 2014

Brains of children with autism teem with surplus synapses

by  /  4 September 2014

The brains of children with autism do not prune unneeded connections between neurons as they age, leaving them with too many of these neuronal links, according to a study published 21 August in Neuron.

July 2014

Distinct features signal autism risk in tuberous sclerosis

by  /  7 July 2014

Children who have both the rare genetic disorder tuberous sclerosis complex and autism show a gradual drop in nonverbal intelligence between 1 and 3 years of age, according to research published 11 June in Neurology.

May 2014

Genetics: Tuberous sclerosis, fragile X share immune changes

by  /  6 May 2014

Two autism-related disorders share disruptions in immune pathways despite major differences in the individual genes affected, according to a study published 24 February in Molecular Autism.

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April 2014
Opinion / Viewpoint

The cerebellum’s surprisingly evolved role in autism

by  /  1 April 2014

Thought until recently to only coordinate motor skills, the cerebellum is involved in diverse cognitive functions such as language and social interaction, and may play a role in autism, says Emanuel DiCicco-Bloom.

January 2014

Mounting evidence implicates cerebellum in autism

by  /  6 January 2014

Results from four studies published in the past year point to a role for the cerebellum in autism-related behaviors.