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Spectrum: Autism Research News

Tag: TSC1

March 2022

Autism model mice develop typical social and motor behaviors after drug treatment

by  /  9 March 2022

The drug suppresses an overactive signaling pathway implicated in tuberous sclerosis complex.

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February 2022
Conceptual illustration of child sleeping under blanket with multiple EEG waves overlaid on top and a window on left showing it is daytime and window on right showing nighttime.

Cracking autism’s sleep conundrum

by  /  25 February 2022

Sleep problems may contribute to or derive from autism traits — or both. After decades of work, researchers are beginning to uncover the biological connections between the two conditions, revealing new paths to potential treatments.

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August 2021

Molecular overlap links tuberous sclerosis, fragile X

by  /  16 August 2021

Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.

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May 2020

Extra proteins alter microglia and behavior in mice

by  /  29 May 2020

The overproduction of proteins in brain cells called microglia causes social impairments, cognitive deficits and repetitive behavior in male mice, a new study has found.

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March 2020
Illustration showing the human brain with neurons made out of flower shapes and the cerebellum highlighted in gold and yellow.

Brain’s motor hub plays unsung role in social skills, cognition

by  /  9 March 2020

Long known as the director of movement, the cerebellum may also coordinate social and cognitive abilities, including those central to autism.

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September 2019
row of babies playing with toys that look like genome sequence

Studies of tuberous sclerosis may shed light on biology of autism

by  /  24 September 2019

Tuberous sclerosis provides a unique opportunity to understand autism because about half of people with that single-gene condition also have autism.

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August 2019

Trial results temper hopes of tumor drug for treating autism

by  /  29 August 2019

A drug that treats tumors and epilepsy in people with tuberous sclerosis complex does not boost their intelligence or ease autism traits.

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November 2018
Purkinje neurons glow red in this section.

Cerebellum’s role in autism may depend on timing

by  /  12 November 2018

Two studies published in the past two months provide new clues to when and how the cerebellum contributes to autism.

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August 2018
Two scientists standing in a lab.

Family ties: Sabatini brothers crack codes that may underlie autism

by  /  30 August 2018

David and Bernardo Sabatini, brothers born just a year and a half year apart, invent their way to answering big questions about autism.

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April 2018

Webinar: Shafali Jeste discusses brain development in high-risk infants

 /  25 April 2018

Watch the complete replay of Shafali Jeste discussing her work investigating brain structure and function in infants at high risk for autism. 

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