As the use of induced pluripotent stem cells grows, researchers are searching for ways to make them behave more predictably.
Spectrum: Autism Research News
Tag: Timothy syndrome
Researchers have uncovered cellular abnormalities in Timothy syndrome by regenerating neurons from individuals with the rare autism-related disorder, according to a study published 27 November in Nature Medicine.
By focusing on recessive mutations inherited from both parents, researchers have identified 50 new candidate genes for intellectual disability.
The ever-curious and energetic Ricardo Dolmetsch is taking skin cells from individuals with various types of autism and turning them into neurons in the lab. The approach could reveal the cellular basis of the disorder and point to new treatments.
Researchers have taken skin cells from individuals with schizophrenia, bathed them in chemical cocktails and coaxed them to develop into neurons, according to a paper published 13 April in Nature.
Rare mutations with strong effects play a key role in autism and schizophrenia, according to a study published in February in PLoS Genetics. The study identifies rare harmful mutations in three candidate genes that are more common in individuals with one of the disorders than in controls.
Accounting for gender increases the power of family-wide studies linking genetic mutations with autism, according to a study published in December in Molecular Psychiatry. The researchers use this approach to identify two candidate genes for the disorder.