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Spectrum: Autism Research News

Tag: synapses

July 2022
Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

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June 2022
A computer-rendered analysis of neurons

Autism-linked mutation disrupts brain circuit to change social behavior

by  /  24 June 2022

Therapies that target the circuit could boost social activity, new findings suggest.

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Two top autism-linked proteins connect to build cell ‘skeleton’

by  /  9 June 2022

ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.

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May 2022
Neuron with dendrites, showing white on solid black.

DDX3X loss affects male, female mouse neurons differently

by  /  12 May 2022

The sex-specific effects may help elucidate why the small number of boys with DDX3X syndrome are born to unaffected mothers.

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SYNGAP1 protein boosts cognition, blocks seizures in mice

by  /  4 May 2022

Ramping up levels of one isoform of the autism-linked protein reverses traits in model mice, a new study shows.

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April 2022

Mini biopsies point to source of lethal seizures in model mice

by  /  26 April 2022

Interneurons that fail to propagate electrical signals in mice that model Dravet syndrome may cause the animals, like people with the autism-linked condition, to die suddenly.

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March 2022
Micrograph of neuron dendrite segments.

Maternal sleep apnea may contribute to autism-like traits in rats

by  /  18 March 2022

Pups born to mothers that experience low oxygen during sleep have overactive mTOR signaling, which has been linked to some forms of autism.

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February 2022
Conceptual illustration of child sleeping under blanket with multiple EEG waves overlaid on top and a window on left showing it is daytime and window on right showing nighttime.

Cracking autism’s sleep conundrum

by  /  25 February 2022

Sleep problems may contribute to or derive from autism traits — or both. After decades of work, researchers are beginning to uncover the biological connections between the two conditions, revealing new paths to potential treatments.

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January 2022
Micrograph showing distinct RNA species found in CA1 hippocampal neuronal cell bodies (yellow) and dendrites (red) undergoing compartmentalized RNA regulation.

Location prompts fragile X protein to flip its function

by  /  31 January 2022

The protein, FMRP, shapes cell signaling near synapses but switches to regulate genes in the cell body, according to new research.

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grid of 12 views of mouse neurons.

Loss of autism-linked gene alters synapse development in mice

by  /  25 January 2022

Mice missing a copy of the gene ASH1L have excess synapses and autism-like behavioral differences, some of which are reversed by boosting an ASH1L-regulated gene.

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