Mice with an extra copy of the autism risk gene UBE3A have cognitive deficits and anxiety, but do not show any core features of the condition.
Researchers have charted gene expression in the brains of rhesus macaques from before birth into adulthood.
Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.
A chemical tag on DNA that has risen to prominence only in the past few years is altered in people with autism, suggest results from an autism mouse model.
A new device lets researchers wirelessly stimulate the brains of rodents as they explore their cages, and can deliver drugs at the same time. Its use could identify brain circuits that mediate autism-like behaviors.
Researchers have for the first time mapped gene expression in the rhesus macaque brain from birth through adulthood. The atlas illuminates the expression patterns of genes likely to be important in autism.
By mapping the connections between autism genes, researchers are finding clues to the disorder’s origins. The key, they say, is to begin without bias.
The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
The motor problems seen in Rett syndrome may be the result of deficits in a reward pathway in the striatum, according to a study published 12 November in Brain Structure and Function.