Striatum
Skewed signaling in striatum may spawn repetitive behaviors
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
Skewed signaling in striatum may spawn repetitive behaviors
Abundant motor proteins disrupt cries in FOXP2 mice
Knocking down the gene that codes for the proteins normalizes the vocalizations.
Abundant motor proteins disrupt cries in FOXP2 mice
Autism’s ties to the cell skeleton
Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
One-rosette technique grows well-organized organoids
Double SHANK knockout highlights brain circuit’s social role
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Double SHANK knockout highlights brain circuit’s social role
Two groups of neurons govern autism-like traits in model mice
Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.
Two groups of neurons govern autism-like traits in model mice
Unfamiliar surroundings bring out autism-like behaviors, brain circuit changes in model mice
A brain area called the tail of the striatum may account for the shift.
Unfamiliar surroundings bring out autism-like behaviors, brain circuit changes in model mice
Loss of autism-linked gene alters synapse development in mice
Mice missing a copy of the gene ASH1L have excess synapses and autism-like behavioral differences, some of which are reversed by boosting an ASH1L-regulated gene.
Loss of autism-linked gene alters synapse development in mice
Brain activity patterns may distinguish girls with autism
Atypical patterns of neuronal activity and gene expression in the striatum may characterize autism in girls, according to a new study.
Brain activity patterns may distinguish girls with autism
Brain activity jump-starts autism-linked genes in human neurons
Some neurons activate autism-linked genes when they fire, according to a new study.
Brain activity jump-starts autism-linked genes in human neurons
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Crowdsourcing to curb aggression in autism: Q&A with Matthew Goodwin
To accelerate the development of real-time behavioral prediction technology, a research team is sharing data and seeking new collaborators.
Crowdsourcing to curb aggression in autism: Q&A with Matthew Goodwin
To accelerate the development of real-time behavioral prediction technology, a research team is sharing data and seeking new collaborators.
Brain connectivity and letting the data speak with Emily Finn
The Dartmouth College researcher talks about her quest to understand behavior and doing neuroscience “in the woods.”
Brain connectivity and letting the data speak with Emily Finn
The Dartmouth College researcher talks about her quest to understand behavior and doing neuroscience “in the woods.”
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.