Neurons grown from human stem cells and grafted onto the brains of live mice mature and form connections like those in the fetal human brain.
Modified stem cells show promise for delivering gene-based therapies to individuals with Angelman syndrome.
Brain organoids made from typical human stem cells begin to show synchronized neuronal firing patterns after growing in a dish for at least four months.
Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.
Two new methods for building ‘mini-brains’ may help researchers study how early brain development differs in people with autism.
Autism and intelligence share genetic variants, researchers grow Neanderthal mini-brains and see overlap with autism, and maternal diabetes is an autism risk factor.
Spheres of brain cells derived from people and implanted into mouse brains recruit blood vessels and integrate with mouse neurons.
Scientists campaign for elected office in record numbers, folate autoantibodies are common in autism families, and neurons form a genetic mosaic in the brain.
Neurons derived from people with mutations linked to autism display diverse abnormalities that may help explain the origins of these individuals’ features.