Tag: stem cells

April 2011
News / Toolbox

Researchers make neurons from people with schizophrenia

by  /  20 April 2011

Researchers have taken skin cells from individuals with schizophrenia, bathed them in chemical cocktails and coaxed them to develop into neurons, according to a paper published 13 April in Nature.

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March 2011
News

Molecular mechanisms: Neuroligin-4 induces synapses in a dish

by  /  23 March 2011

Neuroligin-4, a protein associated with autism, is located at synapses — the junctions between neurons — that inhibit signals in the brain, according to a study published in February in the Proceedings of the National Academy of Sciences. The protein can also single-handedly induce neurons derived from human stem cells to form synapses, according to another study in the same issue.

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News

Root strategy

by  /  11 March 2011

A new technique for creating stem cells from hair may help researchers understand how neurons and the junction between them form.

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First-ever Phelan-McDermid meeting has its Eureka moments

by  /  10 March 2011

The First International Phelan-McDermid Syndrome Symposium, held last week in New York City, brought together scientists and patient advocates to share insights — including a surprising realization about mice missing the SHANK3 gene.

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December 2010
News

Jumping genes implicated in Rett syndrome

by  /  27 December 2010

The neurons of people with Rett syndrome contain an overabundance of retrotransposons — DNA sequences that copy and insert themselves into new spots throughout the genome — during early development, according to a study published 18 November in Nature.

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November 2010
News

Video: Why make neurons from children with autism?

by  /  19 November 2010

Ricardo Dolmetsch is making neurons from induced pluripotent stem cells derived from people with Timothy syndrome, a rare single-gene disorder that causes heart arrhythmias and autism. On Wednesday morning at the Society for Neuroscience annual meeting in San Diego, Dolmetsch talked to SFARI about how this approach could help autism research.

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Immune protein alters development in young mice

by  /  18 November 2010

Pregnant mice injected with the immune protein interleukin-6 give birth to pups that are less social than normal, an effect that results from the over-activation of two pathways critical in neurodevelopment, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.

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News

Researchers make ‘normal’ neurons in a dish

by  /  16 November 2010

A new model system allows scientists to watch human neurons develop outside of the brain, researchers reported Sunday at the Society for Neuroscience annual meeting in San Diego.

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Stem cell assay reveals early development of Rett neurons

by  /  16 November 2010

Researchers have developed the first stem cell system that makes it possible to study the early development of neurons from people with Rett syndrome, a rare disorder on the autism spectrum.

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Stem cells reveal neuroligin’s role in development

by  /  15 November 2010

Stem cell studies show that a mutation in the neuroligin-4 gene disrupts the normal development of synapses, the junction between neurons, according to unpublished data shown Sunday at the Society for Neuroscience annual meeting in San Diego.

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