Siblings of autistic females are more likely to have autism than siblings of autistic males are, and mothers of autistic children carry more common, autism-linked variants than fathers do.
Spectrum: Autism Research News
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The study, which investigated a microRNA’s links to autism, appears to contain duplicated and fabricated data, according to research integrity analysts. Those issues reflect a larger problem in the literature.
Scientists must focus on the importance of representative study samples and of engaging with diverse autism community members.
The approach, tested in mice, selectively boosts the expression of the autism-linked gene SCN1A in a subgroup of inhibitory cells.
The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.
Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.
Different combinations of common, rare, inherited and spontaneous mutations may explain why traits vary so widely among autistic people.
Strategies to replace or compensate for mutated copies of the TCF4 gene could lead to treatments for this profound form of autism, a new study suggests.