Single-cell sequencing
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Vast diversity of human brain cell types revealed in trove of new datasets
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
Autism brain signature most pronounced in sensory areas
An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.
Autism brain signature most pronounced in sensory areas
Glial cells star in autism-linked gene expression analysis
Many genes linked to autism are switched on in the brain's glia, cells that help neurons develop and synapses form.
Glial cells star in autism-linked gene expression analysis
New tool maps cell types in lab-grown blobs of brain tissue
The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.
New tool maps cell types in lab-grown blobs of brain tissue
Intact-cell sequencing lays bare new view of genome structure
The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.
Intact-cell sequencing lays bare new view of genome structure
Atlas maps distinct cell types during earliest stages of brain development
A new atlas profiles gene activity early on during development in the human fetal brain.
Atlas maps distinct cell types during earliest stages of brain development
Brain activity jump-starts autism-linked genes in human neurons
Some neurons activate autism-linked genes when they fire, according to a new study.
Brain activity jump-starts autism-linked genes in human neurons
Atlas pair profiles fetal gene expression, regulation in single cells
A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.
Atlas pair profiles fetal gene expression, regulation in single cells
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What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.
What neuroscientists should know—and what they can do—about changes to BRAIN initiative funding
Many grant proposals submitted to the program in the past year are unlikely to be funded, according to people within the National Institutes of Health. But scientist advocates are reaching out to congressional representatives to try to make changes for 2025.
Crowdsourcing to curb aggression in autism: Q&A with Matthew Goodwin
To accelerate the development of real-time behavioral prediction technology, a research team is sharing data and seeking new collaborators.
Crowdsourcing to curb aggression in autism: Q&A with Matthew Goodwin
To accelerate the development of real-time behavioral prediction technology, a research team is sharing data and seeking new collaborators.
Brain connectivity and letting the data speak with Emily Finn
The Dartmouth College researcher talks about her quest to understand behavior and doing neuroscience “in the woods.”
Brain connectivity and letting the data speak with Emily Finn
The Dartmouth College researcher talks about her quest to understand behavior and doing neuroscience “in the woods.”