The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Spectrum: Autism Research News
Tag: single-cell sequencing
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.
Many genes linked to autism are switched on in the brain’s glia, cells that help neurons develop and synapses form.
The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.
The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.
A new atlas profiles gene activity early on during development in the human fetal brain.
Some neurons activate autism-linked genes when they fire, according to a new study.
A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.