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Spectrum: Autism Research News

Tag: single-cell sequencing

December 2022
lllustration of the junction between two nerve cells.

Multi-omics study captures CNTNAP2’s far-ranging effects

by  /  8 December 2022

The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.

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November 2022
Pink geometric brain against a blue background.

Autism brain signature most pronounced in sensory areas

by  /  2 November 2022

An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.

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December 2021

Glial cells star in autism-linked gene expression analysis

by  /  15 December 2021

Many genes linked to autism are switched on in the brain’s glia, cells that help neurons develop and synapses form.

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July 2021

New tool maps cell types in lab-grown blobs of brain tissue

by  /  29 July 2021

The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.

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April 2021
single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.

Intact-cell sequencing lays bare new view of genome structure

by  /  22 April 2021

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

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Atlas maps distinct cell types during earliest stages of brain development

by  /  1 April 2021

A new atlas profiles gene activity early on during development in the human fetal brain.

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March 2021
A digital rendering of a green neuron on black

Brain activity jump-starts autism-linked genes in human neurons

by  /  5 March 2021

Some neurons activate autism-linked genes when they fire, according to a new study.

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January 2021
human and mouse cells.

Atlas pair profiles fetal gene expression, regulation in single cells

by  /  7 January 2021

A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.

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October 2020
Gut neurons and glia (red, green) are fragile and interwoven with other cells (blue) in the colon, making them tricky to isolate.

Cell maps reveal diversity of neurons in gut

by  /  21 October 2020

An atlas that details gene expression in neurons and other cells from the intestines of mice and people may help to elucidate the link between gut problems and autism.

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October 2019
human cell

In-cell sequencing reveals genome’s natural geometry

by  /  23 October 2019

Researchers have developed a method for sequencing the genome of an intact single cell, revealing its spatial arrangement within the nucleus.

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